Results 221 to 230 of about 6,876 (284)

A Twist in Electronic Relaxation of Pyrimidine Nucleosides and Nucleotides: Impact of C5 Methylation on Nonadiabatic Transition and Photohydration Damage. [PDF]

J Am Chem Soc
Ghosh S, Obara Y, Jaiswal VK, Taddei M, Nenov A, Conti I, Garavelli M, Suzuki T.   +7 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Robotic leaping enhanced by thrust-induced hypogravity, achieving precise, predictable, and extended jumps. [PDF]

Nat Commun
Sun Z, Zhao J, Li Y, Teng L.
europepmc   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Ultrafast spectroscopic signatures for <i>off</i>-to-<i>on</i> photoswitchable species in a green-to-red photoconvertible fluorescent protein. [PDF]

Chem Sci
Krueger TD, Chen C, Fang C.
europepmc   +1 more source

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Explainable transfer learning ensemble AI model for lung ultrasound pneumothorax detection with expert benchmark. [PDF]

Scand J Trauma Resusc Emerg Med
Orosz G, Szabó RZ, Szabó M, Gyombolai P, Tóth JT, Ruttkay T, Ferenci T, Ungi T, Fichtinger G, Haidegger T.   +9 more
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Super-resolution femtosecond electron diffraction reveals electronic and nuclear dynamics at conical intersections. [PDF]

Nat Commun
Jiang H, Zhang J, Wang T, Peng J, Jin C, Zou X, Zhu P, Jiang T, Lan Z, Yong H, He F, Xiang D.   +11 more
europepmc   +1 more source

Textile suit for anywhere full-body motion capture. [PDF]

Sci Adv
Sun H, Feng Y, Kao PC, Black MJ, Kramer-Bottiglio R.   +4 more
europepmc   +1 more source