Results 31 to 40 of about 8,152,883 (248)
Forward and Reverse Mapping for WEDM Process using Artificial Neural Networks [PDF]
Decision Science Letters, 2015 Suitable selection of various machining parameters for wire electrical discharge machining (WEDM) process heavily relies on the operator’s experience and manufacturer’s technologies because of their numerous and diverse operating ranges.
Somen Dey, Shankar Chakraborty
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Asymmetric charge balanced waveforms direct retinal ganglion cell axon growth
Scientific Reports, 2023 Failure to direct axon regeneration to appropriate targets is a major barrier to restoring function after nerve injury. Development of strategies that can direct targeted regeneration of neurons such as retinal ganglion cells (RGCs) are needed to delay ...
M. G. Peng +9 more
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Failure analysis of high voltage thyristor under impulse during reverse recovery period
电力工程技术, 2022 To acquire the characteristic parameters which demonstrate the state of high voltage thyristor for clarifying its failure mechanism, an experiment platform which can not only generate high voltage pulses to thyristor at different moments during reverse ...
YE Mingtian +4 more
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Effect of Current Type and Particle Size on Wear and Corrosion Behaviour of Electroplated Ni-B4C Composite Coatings [PDF]
Iranian Journal of Materials Science and EngineeringNi-B4C nanocomposite coatings were deposited onto a pure Cu substrate using electroplating. Different types of current, including direct current (DC), pulse reverse current (PRC), and unipolar pulse current (PC), were applied using various concentrations
Seyed Ehsan Khadempir +2 more
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Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
Ultrashort-pulse generation from quantum-dot semiconductor diode lasers [PDF]
, 2008 In this thesis, novel regimes of mode locking in quantum dot semiconductor laser diodes have been investigated by exploiting the unique features offered by quantum dots.
Cataluna, Maria Ana
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