Results 161 to 170 of about 2,664,241 (285)

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

open access: yesAdvanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

open access: yesAdvanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang   +8 more
wiley   +1 more source

Triple‐Level Content‐Addressable Vertical NAND Flash Memory

open access: yesAdvanced Science, EarlyView.
Commercial triple‐level‐cell V‐NAND flash memory is transformed into a compact content‐addressable memory by directly exploiting its eight threshold‐voltage states. A parity‐split search scheme preserves storage density while enabling reliable multi‐level and don't‐care matching. Parallel word‐line search delivers up to 24‐fold higher throughput and 54.
Sung‐Ho Park   +8 more
wiley   +1 more source

Development and Performance Assessment of Single- and Double-Layer TbAG:Ce and YAG:Ce Composite Scintillators on GAGG:Ce Substrates for Optimized α-γ Discrimination and Pulse-Shape Analysis. [PDF]

open access: yesMaterials (Basel)
Bachiri A   +10 more
europepmc   +1 more source

Decoupling Fabrication From Encoding: DNA‐Addressable Template Microparticles for Large, User‐Defined Optical Barcode Libraries

open access: yesAdvanced Science, EarlyView.
A universal hydrogel microparticle template with five DNA‐addressable domains decouples particle fabrication from barcode writing. Contact‐free multilaminar flow lithography produces >106 templates/h, and post‐fabrication domain‐selective hybridization converts one batch into large, user‐defined optical barcode libraries with robust decoding and re ...
Akihiro Eguchi   +5 more
wiley   +1 more source

Causal evidence for dorsal stream involvement in object shape recognition: A tractography-guided ccPAS Registered Report study. [PDF]

open access: yesImaging Neurosci (Camb)
Bertacco E   +11 more
europepmc   +1 more source

A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

open access: yesAdvanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li   +15 more
wiley   +1 more source

Antigen‐Detected NMR for Minimal Epitope Engineering and Structure‐Guided Selection of a NaV1.7‐Selective Nanobody

open access: yesAdvanced Science, EarlyView.
A minimal extracellular epitope from voltage‐gated sodium channel NaV1.7 was engineered into an isotope‐labelled antigen for antigen‐detected nuclear magnetic resonance (NMR). Together with AlphaFold2 (AF2), this enabled structure‐guided selection of R4C8, a human NaV1.7‐selective nanobody that labels fixed NaV1.7‐expressing cells and produces staining
Junyu Liu   +27 more
wiley   +1 more source

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