Results 21 to 30 of about 98,095 (251)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Miniature implantable instrument measures and transmits heart function data [PDF]

, 1971
Heart diameter is derived from measured transit time of 2.25 MHz ultrasonic pulse between two piezoelectric crystals attached to diametrically opposite heart surfaces.
Lee, R. D.
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Speed-of-light pulses in the massless nonlinear Dirac equation with a potential [PDF]

, 2017
We consider the massless nonlinear Dirac (NLD) equation in $1+1$ dimension with scalar-scalar self-interaction $\frac{g^2}{2} (\bar{\Psi} \Psi)^2$ in the presence of three external electromagnetic potentials $V(x)$, a potential barrier, a constant ...
Bishop, A. R., Cooper, Fred, Mertens, Franz G., Quintero, Niurka R., Saxena, Avadh   +4 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transit Time and Charge Correlations of Single Photoelectron Events in R7081 PMTs

, 2012
During the calibration phase of the photomultiplier tubes (PMT) for the Double Chooz experiment the PMT response to light with single photoelectron (SPE) intensity was analysed.
C Langbrandtner, C. Aberle ., C. Bauer ., Double Chooz collaboration, F Kaether, J. Haser .   +5 more
core   +4 more sources

Cuff-Less Methods for Blood Pressure Telemonitoring. [PDF]

, 2019
Blood pressure telemonitoring (BPT) is a telemedicine strategy that uses a patient\u27s self-measured blood pressure (BP) and transmits this information to healthcare providers, typically over the internet.
Bard, Dylan M., Joseph, Jeffrey I., van Helmond, Noud   +2 more
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Pulse transit time confirms altered response to spinal anaesthesia in pregnancy induced hypertension [PDF]

, 2011
Poster presented at the International Society for the Study of Hypertension in Pregnancy (ISSHP)Congress, Toronto 2002.Part of the Portfolio Thesis by Geoffrey H.
Bruce, J., Drummond, G., Sharwood-Smith, Geoffrey H.   +2 more
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source