Results 31 to 40 of about 35,769 (244)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Sexualidad y virtualidad : algunas coordenadas para pensar el fenómeno del sexting desde el psicoanálisis [PDF]
, 2016 El sexting, entendido como el envío de fotos o videos eróticos a través de medios digitales, es una práctica cada vez más extendida. ¿De qué se tratan estas prácticas? ¿qué características de la época ayudarían a explicar el fenómeno? Y fundamentalmente,
Arias, Valentina
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Redención de un orden material en la escultura de William Tucker [PDF]
, 2016 Con las esculturas presentadas por William Tucker a partir de mediados de los ochenta, su obra -y en ello expone las búsquedas y el sentido de la cultura contemporánea- asume un grado fundacional en el sentido de que pasa del mero concepto, de un primer ...
Aguirre Martínez, Guillermo
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Representación en psicoanálisis [PDF]
, 2003 La representación interna o subjetiva es aquella que el individuo constituye dentro de sí mismo Lo representado puede ser tanto lo que viene del mundo externo como lo que viene del interior del individuo En este trabajo nos centraremos en la ...
Minhot, Leticia O.
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Crónica de una muerte anunciada: caso de una neurosis obsesiva [PDF]
, 2013 El propósito del Estudio de Caso Psicoanalítico fue plantear la Dinámica Edipica que dio pie a la estructura de un caso de Neurosis Obsesiva, así como su Pulsión de Muerte; además el objetivo fue en un paciente con esta estructura, como se vinculó ...
Rosales Hernández, Guillermo
core