Results 41 to 50 of about 35,769 (244)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Eros, Tánatos y el minotauro la dualidad pulsional de la teoría psicoanalítica freudiana, a través de la serie pictórica del minotauro en la obra de Picasso [PDF]
, 2014 En un esfuerzo por dar un giro al vínculo que comúnmente se ha establecido entre arte y psicoanálisis, como es la interpretación del arte, el interés de este trabajo de grado es partir desde el arte como herramienta de interpretación para posteriormente ...
Caballero Aldana, Mayra Angélica +1 more
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Bachelard y Freud. Los actos epistemológicos [PDF]
, 1998 Intentamos hoy continuar un diálogo entre Bachelard y Freud, deteniéndonos particularmente en la cuestión de los "actos epistemológicos". Como el trabajo que presentáramos en las Vil Jornadas, éste se halla enmarcado en el Proyecto de Investigación ...
Becerra Batan, Marcela Renée +1 more
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The paths of sublimation in Freud's oeuvre [PDF]
, 2012 Indexación: Web of ScienceEl presente trabajo distingue el concepto de sublimación en diferentes momentos a lo largo de la obra de Freud. Su propósito es contrastarlo con otros conceptos, sin asumir la primacía de algunos obre otros, sino para ...
Bornhauser, Niklas, Ochoa, Diego
core +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Guía de lectura de "El malestar en la cultura" - Corrientes actuales de la filosofía (Curso 2010-11) [PDF]
, 2010 Depto. de Lógica y Filosofía TeóricaFac.
Sánchez Madrid, Nuria
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FEBS Open Bio, EarlyView.This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source