Results 221 to 230 of about 22,047 (273)

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

open access: yesAdvanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi   +15 more
wiley   +1 more source

ACSL1‐Dependent Microglial Lipoimmunometabolic Reprogramming Underlies Cognitive Deficits in Alcohol Use Disorder

open access: yesAdvanced Science, EarlyView.
This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao   +8 more
wiley   +1 more source

Acoustic Rising Microbubbles for Efficient Liquid Operations. [PDF]

open access: yesCyborg Bionic Syst
Bai C   +8 more
europepmc   +1 more source

Smart ultra-long-lasting sequentially triggerable and artfully implantable nozzle system for on-demand drug delivery for chronotherapy. [PDF]

open access: yesSci Adv
Zeng Q   +14 more
europepmc   +1 more source

Octopus-Inspired Self-Adaptive Hydrogel Gripper Capable of Manipulating Ultra-Soft Objects. [PDF]

open access: yesNanomicro Lett
Wang Y   +11 more
europepmc   +1 more source

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