Results 111 to 120 of about 2,535,910 (353)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Dependence of quantum correlations of twin beams on pump finesse of optical parametric oscillator
, 2007 The dependence of quantum correlation of twin beams on the pump finesse of an optical parametric oscillator is studied with a semi-classical analysis.
Changde Xie +9 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Na+/K+-pump and neurotransmitter membrane receptors
Invertebrate Neuroscience, 2018 Na+/K+-pump is an electrogenic transmembrane ATPase located in the outer plasma membrane of cells. The Na+/K+-ATPase pumps 3 sodium ions out of cells while pumping 2 potassium ions into cells. Both cations move against their concentration gradients. This
A. S. Pivovarov, F. Calahorro, R. Walker
semanticscholar +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
A Review of Gerotor Technology in Hydraulic Machines
Energies, 2019 Over the years, numerous investigations have established the gerotor fundamentals. This work aims to provide a complete review of the literature from the last decade, focusing on the articles published in the past five years on gerotor technology in ...
Pedro Javier Gamez-Montero +2 more
doaj +1 more source
The stochastic pump current and the non-adiabatic geometrical phase
, 2008 We calculate a pump current in a classical two-state stochastic chemical kinetics by means of the non-adiabatic geometrical phase interpretation. The two-state system is attached to two particle reservoirs, and under a periodic perturbation of the ...
Arnold V I +14 more
core +1 more source
, 2017 Previous studies on the effect of mass uptake of heat pumps on the capability of local or national electricity grids have relied on modelling or small datasets to create the aggregated heat pump load profile.
J. Love +11 more
semanticscholar +1 more source