Results 121 to 130 of about 2,535,910 (353)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Polarization dependent Brillouin gain in randomly birefringent fibers

, 2009
An extensive study of the alignment between the pump, the signal and the polarization dependent gain (PDG) vectors in stimulated Brillouin amplification in randomly birefringent fibers is realized by numerically integrating the equations governing the ...
Palmieri, Luca, Santagiustina, Marco, Ursini, Leonora   +2 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Selective hydrometallurgical recovery of gold by using low-cost biomass waste: Kiwi peel

Adsorption Science & Technology
Utilization of kiwi peel (KP) is proposed for gold recovery from electronic wastes (e-wastes). KP was simply modified by dehydration pretreatment with concentrated sulfuric acid.
Dan Yu, Xiaomei Guo, Yang Liu
doaj   +1 more source

Design study of a novel regenerative pump using experimental and numerical techniques [PDF]

, 2010
This paper presents a numerical and experimental analysis of a new regenerative pump design. The complex flow-field within regenerative pumps represents a significant challenge to previous published mathematical models. The new pump design incorporates a
Baumgartner, B., Quail, Francis J., Stickland, M.T.   +2 more
core  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A sharp MLS penalty immersed finite element method for fluid-structure interaction of highly deformable slender body in turbulent flow

Engineering Applications of Computational Fluid Mechanics
This paper presents a new computational approach to simulate challenging fluid-structure interactions (FSI) between fluids and slender deformable structures.
Ehsan Akrami, Mathieu Specklin, Rafael Torrecilla Rubio, Robert Connolly, Ben Breen, Stefan Berten, Mark Kehoe, Abdulaleem Albadawi, Yan Delaure   +8 more
doaj   +1 more source

Pump and Pumping System

Advances in Mechanical Engineering, 2014
1 National Research Center of Pumps and Pumping System, Engineering and Technology, Jiangsu University, Zhenjiang 212013, China 2 Institute of Fluid Machinery, Tsinghua University, Beijing 100084, China 3 School of Fluid Power and Controlling, University of Science and Technology, Lanzhou 730050, China 4 Institute of Chemical Machinery, Zhejiang ...
Weidong Shi, Wang Zheng-Wei, Li Ren-Nian, Leqin Wang, Shibo Kuang   +4 more
openaire   +2 more sources

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source