Results 91 to 100 of about 271,894 (285)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PIV experimental study on the flow field characteristics of axial flow blood pump under three operating conditions

The Journal of Engineering, 2018
In order to investigate the internal flow field of an axial blood pump, two-dimensional (2D) particle image velocimetry (PIV) was applied to test the blood pump under three different conditions.
Zhiyong Xiao, Jianping Tan, Shuai Wang, Zheqin Yu, Weiqiang Wu   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Design and analysis on the flow fluctuation of a new horizontal space multiphase crankshaft pump

The Journal of Engineering, 2018
In civil aviation ground deicing system, the traditional reciprocating pump is often used as the power supply device to ensure the physical and chemical properties of high viscosity deicing fluid.
Mengli Wu, Xianqu Yue, Yunpeng Li, Weibin Chen, Qi Nie, Fei Chen, Liwen Wang   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Stability of Air Nucleus in Liquid Water and Cavitation Inception on Marine Engineering

Polish Maritime Research, 2018
The micro air nucleus widely distributed in the ocean is a necessary condition for the cavitation of hydraulic machinery in seawater. In order to study the stability of air nucleus in seawater and cavitation inception, the computational domain of water ...
Qiang Fu, Ming Chen, Xiuli Wang, Rongsheng Zhu, Guoyu Zhang, Jianen Yu   +5 more
doaj   +1 more source

Dynamic security of islanded power systems with pumped storage power plants for high renewable integration – A study case

The Journal of Engineering, 2019
This work consists in assessing a real islanded power system from a dynamic security point of view, to support the planned installation, in the near future, of a hydro power plant with pumped storage, aiming to increase the integration of renewable ...
Maria Helena Vasconcelos, Pedro Beires, Pedro Beires, Carlos Leal Moreira, João Abel Peças Lopes   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

An analytical and experimental investigation of three phase flow in airlift pumps used for diamondiferous marine gravel reclamation [PDF]

, 1991
Bibliography: leaves 75-79.This dissertation covers an investigation on airlift pumps operating in three phase flow. The investigation is specifically geared towards offshore diamond reclamation and the three phases considered are air, water and marine ...
Berg, R Rainer
core   +1 more source