Results 51 to 60 of about 165,258 (265)

Flow Inside the Sidewall Gaps of Hydraulic Machines: A Review

Energies, 2020
The paper critically reviews the current state of the art in flow inside sidewall gaps of hydraulic pumps and turbines. It describes the consequences of the presence of this type of flow in turbomachinery and then relates it to other physical phenomena ...
Lucie Zemanová, Pavel Rudolf
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Direct Shape Optimization and Parametric Analysis of a Vertical Inline Pump via Multi-Objective Particle Swarm Optimization

Energies, 2020
The vertical inline pump is a single-suction single-stage centrifugal pump with a curved inlet pipe before the impeller, which usually causes a significant increase of hydraulic losses in the inline pump. Considering the matching relationship between the
Xingcheng Gan, Wenjie Wang, Ji Pei, Shouqi Yuan, Yajing Tang, Majeed Koranteng Osman   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

From Geometric Regulation to Intelligent Design: A Review on Performance Improvement of Dual-Feedback Fluidic Oscillators

Machines
Fluidic oscillators (FOs) are self-excited jet-generating devices without moving parts that convert steady fluid supply into oscillatory jets through inherent flow instabilities.
Ye Chu, Henghui Liao, Guo Tang, Hao Chang   +3 more
doaj   +1 more source

Performance Prediction Based on Effects of Wrapping Angle of a Side Channel Pump

Energies, 2019
This paper seeks to predict the performance of the side channel pump by considering the influences of different wrapping angles. Firstly, three pump cases 1, 2 and 3 are modeled with wrapping angles 15°, 30° and 45°, respectively.
Ji Pei, Fan Zhang, Desmond Appiah, Bo Hu, Shouqi Yuan, Ke Chen, Stephen Ntiri Asomani   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Experimental Investigations on the Inner Flow Behavior of Centrifugal Pumps under Inlet Air-Water Two-Phase Conditions

Energies, 2019
Centrifugal pumps are widely used and are known to be sensitive to inlet air-water two-phase flow conditions. The pump performance degradation mainly depends on the changes in the two-phase flow behavior inside the pump.
Qiaorui Si, Haoyang Zhang, Gérard Bois, Jinfeng Zhang, Qianglei Cui, Shouqi Yuan   +5 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source