Results 41 to 50 of about 30,150 (294)

NOTCH2NLC Repeat Expansions in Parkinsonian Disorders: Clinical and Neuroimaging Characteristics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder caused by NOTCH2NLC GGC repeat expansions, with heterogeneous clinical manifestations, including parkinsonism. Recent studies have identified NOTCH2NLC repeat expansions in patients with Parkinson's disease (PD) and atypical parkinsonism (aPM), suggesting ...
Han‐Lin Chiang, Kang‐Yang Jih, Cheng‐Tsung Hsiao, Fu‐Pang Chang, Justus Chunyu Chen, Yi‐Chu Liao, Yih‐Ru Wu, Yi‐Chung Lee   +7 more
wiley   +1 more source

Punching of Ultra-High-Strength Spring Strips: Evolution of Cutting Edge Radius up to 1,000,000 Strokes for Three Punch Materials

Journal of Manufacturing and Materials Processing, 2022
Punching of ultra-high-strength spring steel causes critical stresses in the tools. Pronounced wear and even spontaneous failure may occur. Wear of the punches influences the quality of the cutting surfaces of the blanked parts, which is predominantly ...
Sven Winter, Karsten Richter, Elmar Galiev, Matthias Nestler, Verena Psyk, Verena Kräusel   +5 more
doaj   +1 more source

Assessment of skin in patients with systemic sclerosis using high‐frequency ultrasound and shear wave elastography: A comparative study with histology, molecular and clinical parameters

Arthritis Care &Research, Accepted Article.
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histological markers of skin fibrosis has not been reported. We evaluated the US‐based skin assessments for their face validity (differentiation between involved SSc and ...
Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L. Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin, Maureen Mayes, Shervin Assassi   +12 more
wiley   +1 more source

Derivation of Point Plot-based Ductile Fracture Loci through Assimilation of Finite Element Simulation and Individual Actual Punched Surface Profile [PDF]

MATEC Web of Conferences
This study demonstrated the inverse identification of the ductile fracture locus (DFL), successfully reproducing the actual punched surface profiles of DP980 steels.
Matsuno Takashi, Eguchi Jin, Kunii Yasuhiro, Shimizu Kazuyuki, Matsuki Yuichi, Shinmiya Toyohisa, Iizuka Eiji   +6 more
doaj   +1 more source

Using a Supramolecular Approach to Engineer Modular Hydrogel Platforms for Culturing Protoplasts – from General Tissue Engineering to Cellular Agriculture

Advanced Biology, EarlyView.
Using supramolecular monomers, various hydrogel culture systems were formulated to culture protoplasts; including 2D, 2.5D, and 3D hydrogels. Depending on the culture platform, bioactive functionalization led to protoplast enlargement (2D and 2.5D) or plasmolysis (3D). This work shows the potential to modularly engineer synthetic platforms for cellular
Maritza M. Rovers, Erik J. Slootweg, Ferdinand C. O. Los, Patricia Y. W. Dankers   +3 more
wiley   +1 more source

Finite Element Analysis of the Bearing Capacity of Beamless Floor Slabs under Punching, Taking into Account the Design Parameters of the Contacting Elements

Buildings, 2023
Static calculations of experimental models in an elastic formulation were carried out, and the regularities connecting the dependences of forces in the calculated cross-section of punching out from the main structural parameters of contacting elements ...
Tatiana Matseevich
doaj   +1 more source

Amide‐Linked Local Anesthetics Alter Tumor Biology in a Complex Human Tissue Model of Non‐Small Cell Lung Adenocarcinoma

Advanced Biology, EarlyView.
Amide local anesthetics (LA) affect tumor burden in various preclinical studies, possibly via their anti‐inflammatory properties. However, a translation into clinical evidence is still lacking. The current study demonstrates that LA ‐ even at clinically relevant concentrations – exert a strong anti‐tumoral effect in a complex ex vivo model patient ...
Juliane Krömer, Sebastian Krämer, Ngoc Anh Hoang, Doreen Sittig, Isabella Metelmann, Uta‐Carolin Pietsch, Sebastian N. Stehr, Sonja Kallendrusch, Tobias Piegeler   +8 more
wiley   +1 more source

A New Nozzle for Continuous Inkjet Printers

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2010
The shape of a nozzle for high-quality printing was optimized by using a standard, robust design method, and a method for fabricating the optimized nozzle was established.
Mamoru OKANO, Tomohiro INOUE, Yoshiharu TAKIZAWA, Tadayuki MATSUDA, Akira MIYAO   +4 more
doaj   +1 more source

The Last Punch [PDF]

Ufahamu: A Journal of African Studies, 1983
No ...
openaire   +3 more sources

Tribology of ZrC Coatings and Spherical Tips Acquired with Extraordinarily Stiff, Metal Atomic Force Microscopy Probes

Advanced Engineering Materials, EarlyView.
In this research, ZrC coatings are evaluated against various counterprobes at the microscale using novel super‐stiff atomic force microscopy cantilevers. The chemical composition of the coating is shown to be an important factor influencing coating hardness and Young's modulus, while surface roughness, counterprobe hardness, and surface energy are the ...
Piotr Jenczyk, Marcin Michałowski, Bogdan Warcholiński, Michał Milczarek, Adam Gilewicz   +4 more
wiley   +1 more source