Results 41 to 50 of about 92,897 (298)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Guidewire‐assisted successful closure of mis‐punctured transverse colon during endoscopic ultrasound‐guided cyst drainage

DEN Open
Endoscopic ultrasound‐guided cyst drainage (EUS‐CD) was performed for walled‐off pancreatic necrosis. Computed tomography performed the next day showed that the tip of the external drainage tube was located in the transverse colon, confirming an ...
Naoki Fujita, Hideki Kamada, Ryota Nakabayashi, Takuma Yamashita, Shima Mimura, Hiroki Yamana, Kiyoyuki Kobayashi, Minoru Oshima, Keiichi Okano, Hideki Kobara   +9 more
doaj   +1 more source

Conformal blocks on a 2-sphere with indistinguishable punctures and implications on black hole entropy

Physics Letters B, 2016
The dimensionality of the Hilbert space of a Chern–Simons theory on a 3-fold, in the presence of Wilson lines carrying spin representations, had been counted by using its link with the Wess–Zumino theory, with level k, on the 2-sphere with points (to be ...
Abhishek Majhi
doaj   +1 more source

Intrathecal nusinersen administration in adult spinal muscular atrophy patients with complex spinal anatomy

Therapeutic Advances in Neurological Disorders, 2020
Background: Intrathecal administration of nusinersen in adult spinal muscular atrophy (SMA) patients presents challenges owing to severe scoliosis and previous spinal surgery with metal implantation.
Isabell Cordts, Paul Lingor, Benjamin Friedrich, Verena Pernpeintner, Claus Zimmer, Marcus Deschauer, Christian Maegerlein   +6 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Outcomes of Endoscopic Ultrasound-Guided Hepaticogastrostomy Using a 22G Needle Combined with a Double-Guidewire Technique

Journal of Digestive Endoscopy
Objectives Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is an increasingly used alternative treatment for malignant biliary obstructions. However, improvements to this approach are warranted.
Toru Kaneko, Mitsuhiro Kida, Takahiro Kurosu, Gen Kitahara, Shiori Koyama, Tomohiro Betto, Chika Kusano   +6 more
doaj   +1 more source

On the complexity of braids [PDF]

, 2006
We define a measure of "complexity" of a braid which is natural with respect to both an algebraic and a geometric point of view. Algebraically, we modify the standard notion of the length of a braid by introducing generators $\Delta\_{ij}$, which are ...
Dynnikov, Ivan, Wiest, Bert
core   +2 more sources

Phase-space and Black Hole Entropy of Higher Genus Horizons in Loop Quantum Gravity

, 2008
In the context of loop quantum gravity, we construct the phase-space of isolated horizons with genus greater than 0. Within the loop quantum gravity framework, these horizons are described by genus g surfaces with N punctures and the dimension of the ...
A DeBenedictis, Ansari M H, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A, Ashtekar A Pawlowski T Van Den Broeck C, Bojowald M, Carlip S, Carlip S, Chandrasekhar S, Chatterjee A Majumdar P, Corichi A, Domagala M, Ghosh A, Govindarajan T R, J Brannlund, Jacobson T, Lewandowski J, Liko T, Majumdar P, Meissner K A, Meissner K A, Mena F C Natário J Tod P, Modesto L, Nakahara M, Olea R, Perez A, Rovelli C, S Kloster, Tamaki T, Thiemann T, Wald R M   +35 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source