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Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source
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The pupil

Current Opinion in Neurology, 2008
To give an overview on topics of pupillary function selected according to their relevance in clinical neurology. Mainly publications of the last 3 years have been considered.The discovery of photosensitive retinal ganglion cells not serving vision, but serving circadian rhythm and the pupil initiated many studies.
openaire   +2 more sources

The Pupil

Continuum, 2019
The goal of this article is to review the anatomy and physiology of pupillary function and then employ that information to develop a comprehensive framework for understanding and diagnosing pupillary disorders.The contribution of rods and cones to the pupillary light reflex has long been known.
openaire   +2 more sources

Pupils and Accommodation

2016
There are two kinds of muscles in the eyes: extraocular muscles, which move the ocular bulb, and intraocular muscles, which are innervated by the autonomic nervous system. The intraocular muscles have two functions; one controls the diameter of pupils and the other controls thickness of the lens (accommodation). For examining the ocular muscles, we can
Hiroshi Shibasaki, Mark Hallett
openaire   +1 more source

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