Results 121 to 130 of about 40,657 (306)

Restructuring and hospital care: Sub-national trends, differentials, and their impacts; New Zealand from 1981

, 2009
An analysis of the "nation's health" is the central concern of this study. Its genesis was a detailed, technical, time-series research on regional and ethnic differentials in health in New Zealand.
Jackson, Gary, Sceats, Janet E., Cooper, Jenine, Cheung, Jit, Dharmalingam, Arunachalam, Coombs, Ngaire, Pool, Ian, Katzenellenbogen, Judith M., Baxendine, Sandra   +8 more
core  

The effect of Meropenem stewardship at Prof Ngoerah Hospital on the prevalence of carbapenem resistant Acinetobacter baumannii, Carbapenem-resistant Pseudomonas aeruginosa and the cost of purchasing meropenem

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Irrational use of antibiotics will trigger anti-microbial resistance which is a threat to health problems now and in the future. The use of meropenem is often the last choice in using antibiotics without undergoing microbiological examination
Made Susila Utama, Reza Andriani, Wayan Suranadi, Dwi Fatmawati   +3 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

The implications of hospital value-based purchasing on academic medical centers

, 2017
Academic Medical Centers (AMCs) are an integral component of the health care system in the United States. With such a unique purpose and sweeping influence, AMCs play an indispensable role in transforming the health care delivery system.
LoNigro, Adam
core  

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

The Group Purchasing Organization's Economic Value to the Not-For-Profit Hospital: What are the Determinants of Value?

, 2014
There exists today a symbiotic relationship between the Not-For-Profit (NFP) hospital and the healthcare Group Purchasing Organization (GPO). This relationship is based on a business model which creates a revenue stream for the GPO based on fees ...
Silverman, David Abbott.
core   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Participatory Approaches to Purchasing Decisions within the Healthcare System

, 2013
The main purpose of this study was to use sociotechnical and Macroergonomic principles to better understand purchasing policies and procedures at a large hospital.
Dorris, Alana
core   +1 more source

The importance of physician to physician coaching, medical director and staff engagement and doing “one thing different”

Patient Experience Journal, 2019
With the Center for Medicare and Medicaid Services incorporating patient experience into the Value Based Purchasing metrics, there is increasing hospital focus on improving this important aspect of patient care.
Ghazala Sharieff
doaj