Results 231 to 240 of about 263,843 (312)

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Managed Competition in Healthcare (?) Comment on "Measuring Active Purchasing in Healthcare: Analysing Reallocations of Funds Between Providers to Evaluate Purchasing Systems Performance in the Netherlands". [PDF]

Int J Health Policy Manag
Nemec J.
europepmc   +1 more source

NIPAL1 Drives a Metabolic‐Epigenetic Feedback Loop to Promote Lactate‐Mediated Immune Evasion in Esophageal Cancer

Advanced Science, EarlyView.
The study identifies a NIPAL1‐driven metabolic‐epigenetic circuit in esophageal squamous cell carcinoma that promotes glycolysis, lactate accumulation, and H3K18 histone lactylation, forming a self‐sustaining loop that suppresses CD8+ T cell immunity.
Ri‐Xin Chen, Xiao‐Dan Ma, Shui‐Dan Xu, Ao‐Tian Mo, Min‐Hua Deng, Jun‐Han Wu, Wei‐Tao Zhuang, Jin‐Ling Duan, Shu‐Huan Xie, Jin‐Long Lin, Peng Lin, Ji‐Ming Tang, Hai‐Yu Zhou, Xiao‐Song Ben, Gui‐Bin Qiao, Dan Xie   +15 more
wiley   +1 more source

Barriers to airway procurement processes in sub-Saharan Africa: An exploratory qualitative study. [PDF]

J Coll Med S Afr
Patel NR, Kabagenyi F, Tshite F, Barnor I, Abdalla T, Maina R, Wiedermann J, Jacobson L, Okerosi S, Balakrishnan K, Patterson RH, Sidell D, Xu MJ, Din T.   +13 more
europepmc   +1 more source

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source

Using the advantages and avoiding the risks - a public survey about the challenges of online purchases of medicines. [PDF]

Scand J Prim Health Care
Persson A, Troein M, Jakobsson U, Lundin S, Midlöv P, Lenander C.   +5 more
europepmc   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

The association between adolescents' independent food purchasing and dietary quality differs by socioeconomic status: Findings from a pilot study. [PDF]

PLoS One
Shaw S, Crozier S, Cooper C, Smith D, Barker M, Vogel C.   +5 more
europepmc   +1 more source

Greenhouse gas emissions associated with anaesthetic gases in Australia, 2002-2022: a retrospective descriptive analysis. [PDF]

Med J Aust
Verlis K, Davies JF, McGain F, Burch H, Barratt AL, Kazda L.   +5 more
europepmc   +1 more source

Assessment of the medical equipment supply chain in the Democratic Republic of Congo: a qualitative methods study. [PDF]

BMC Health Serv Res
Niles J, Bosonkie M, Lusamba-Dikassa PS, Wisniewski J.   +3 more
europepmc   +1 more source