Results 61 to 70 of about 40,657 (306)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Hospital Value-Based Purchasing Performance

open access: yes, 2018
The hospital value-based purchasing (HVBP) program of the Centers for Medicare & Medicaid Services challenges hospitals to deliver high-quality care or face a reduction in Medicare payments.
Mei Zhao   +5 more
core   +1 more source

The impact of COVID-19 on supply decision-makers: the case of personal protective equipment in Spanish hospitals

open access: yesBMC Health Services Research, 2021
Background The COVID-19 pandemic has been recognized as a trigger for redefining supply chains at the global level, and has created an intense debate within the academic community and among policy-makers and practitioners.
Manuel F. Morales-Contreras   +2 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

open access: yesFEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan   +11 more
wiley   +1 more source

Value-based purchasing, efficiency, and hospital performance

open access: yes, 2015
The Medicare hospital value-based purchasing (HVBP) program that links Medicare payments to quality of care became effective in 2013 in the United States. Hospital efficiency will be added to the HVBP in 2015.
Haley, D. Rob   +3 more
core   +1 more source

Potential of Local Food Use in the Ohio Health Care Industry: An Exploratory Study

open access: yesJournal of Agriculture, Food Systems, and Community Development, 2016
Institutionalized foodservice in health care is evolving. Some hospitals have introduced local foods as a means of improving health and wellness. Investigation into the hospital foodservice literature, however, leaves unclear what percentage of hospitals
Brian Raison, Scott D. Scheer
doaj   +1 more source

THE EFFECT OF SERVICE QUALITY AND HOSPITAL IMAGES ON PATIENT SATISFACTION (Survey of Outpatients at Saraswati Cikampek General Hospital)

open access: yesManajemen Bisnis, 2020
This study aims to examine and analyze the effect of service quality and hospital image on outpatient satisfaction at the Saraswati Cikampek General Hospital.
Diana Rizqiah Diputri, Abdul Yusuf
doaj   +1 more source

Problematic Internet Use in Frontotemporal Dementia: A Case Series

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The present study investigated problematic internet use (PIU) among 61 patients with frontotemporal dementia (FTD) compared to a cohort of 354 patients with mild cognitive impairment (MCI) and Alzheimer's dementia. PIU was identified in 22.9% of FTD patients compared to only 0.8% of AD patients (p < 0.001). Behaviors included compulsive social
Daniele Urso   +9 more
wiley   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

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