Results 11 to 20 of about 174,314 (331)

Pure Autonomic Failure with Asymptomatic Hypertensive Urgency: A Case Report and Literature Review [PDF]

Case Reports in Neurology, 2018
We report the case study of a 70-year-old gentleman who presented with isolated, slowly progressive dizziness after prolonged standing and was eventually diagnosed with pure autonomic failure.
Alwaleed Aljohar, Taim Muayqil, Abdulrahman Aldeeri, Anwar Jammah, Ahmad Hersi, Khalid Alhabib   +5 more
doaj   +4 more sources

Pure Autonomic Failure. [PDF]

Mayo Clin Proc, 2019
Pure autonomic failure (PAF) is a neurodegenerative disorder of the autonomic nervous system clinically characterized by orthostatic hypotension. The disorder has also been known as Bradbury-Eggleston syndrome, named for the authors of the 1925 seminal description.
Coon EA, Singer W, Low PA.
europepmc   +10 more sources

Alpha-Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure. [PDF]

Ann Neurol, 2021
To explore the role of alpha‐synuclein (αSyn) oligomers and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) of patients with pure autonomic failure (PAF) as markers of future phenoconversion to multiple system atrophy (MSA).
Singer W, Schmeichel AM, Shahnawaz M, Schmelzer JD, Sletten DM, Gehrking TL, Gehrking JA, Olson AD, Suarez MD, Misra PP, Soto C, Low PA.   +11 more
europepmc   +4 more sources

Pure autonomic failure versus prodromal dysautonomia in Parkinson’s disease: Insights from the bedside. [PDF]

Mov Disord Clin Pract, 2017
Autonomic failure may include orthostatic hypotension, supine hypertension, bowel and bladder disturbances, impaired thermal regulation, and sexual dysfunction, all of which can be features of Parkinson's disease (PD) and other a‐synucleinopathies.
Merola A, Espay AJ, Zibetti M, Romagnolo A, Rosso M, Maule S, Lopiano L.   +6 more
europepmc   +5 more sources

Central Involvement in Pure Autonomic Failure: Insights from Neuromelanin-Sensitive Magnetic Resonance Imaging and ¹⁸F-Fluorodopa-Positron Emission Tomography. [PDF]

Mov Disord
Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and locus coeruleus (LC). Pure
Trujillo P, O'Rourke KR, Roman OC, Song AK, Hett K, Cooper A, Black BK, Donahue MJ, Shibao CA, Biaggioni I, Claassen DO.   +10 more
europepmc   +3 more sources

Renal impairment of pure autonomic failure. [PDF]

Hypertension, 2009
Supine hypertension is difficult to manage in patients with pure autonomic failure (PAF), because treatment can worsen orthostatic hypotension. Supine hypertension in PAF has been associated with left ventricular hypertrophy, but end organ damage in the kidney has not been assessed.
Garland EM, Gamboa A, Okamoto L, Raj SR, Black BK, Davis TL, Biaggioni I, Robertson D.   +7 more
europepmc   +6 more sources

RBD in pure autonomic failure [PDF]

Journal of Clinical Images and Medical Case Reports, 2021
Pure autonomic failure is considered to be a degenerative condition of the autonomic nervous resulting from accumulation of alpha-synuclein in autonomic ganglia [1,2]. Lack of CNS involvement distinguishes this disorder from other synucleopathies with CNS involvement like MSA, DLB and PD. However, long term follow-up of PAF patients has shown that some
Shabeer Ahmad Paul, Chandrakanta Patra, Gouranga Prasad Mondal, Ramesh Bhattacharyya, K. Ghosh, Sarbajit Das   +5 more
semanticscholar   +3 more sources

Natural history of pure autonomic failure: A United States prospective cohort. [PDF]

Ann Neurol, 2017
Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D, Autonomic Disorders Consortium.   +12 more
europepmc   +4 more sources

Very late-onset pure autonomic failure. [PDF]

Mov Disord, 2017
Fanciulli A, Stefanova N, Scherfler C, Moser P, Seppi K, Gizewski ER, Virgolini I, Boesch S, Poewe W, Wenning GK.   +9 more
europepmc   +5 more sources

Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study. [PDF]

Brain
We aimed to describe the clinical features of patients with pure autonomic failure (PAF) preceding phenoconversion that could be useful as predictive markers for advancing α-synuclein-associated neurodegeneration of the brain. Patients diagnosed with PAF
Millar Vernetti P, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Shibao CA, Peltier A, Freeman R, Gibbons C, Goldstein DS, Low PA, Singer W, Coon EA, Miglis MG, Wenning GK, Fanciulli A, Vernino S, Betensky RA, Kaufmann H.   +17 more
europepmc   +2 more sources