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Neurology, 2010
The disorder now called pure autonomic failure (PAF) was first described by Bradbury and Eggleston1 in 1925. The original report included 3 patients with chronic postural hypotension and frequent episodes of syncope, a relatively slow and unchanging pulse rate, reduced sweating, erectile dysfunction, and constipation.
Horacio Kaufmann, David S. Goldstein
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The disorder now called pure autonomic failure (PAF) was first described by Bradbury and Eggleston1 in 1925. The original report included 3 patients with chronic postural hypotension and frequent episodes of syncope, a relatively slow and unchanging pulse rate, reduced sweating, erectile dysfunction, and constipation.
Horacio Kaufmann, David S. Goldstein
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Pure Autonomic Failure – eine seltene Ursache orthostatischer Intoleranz
Erfahrungsheilkunde, 2022Zusammenfassung Bei Patienten mit seltenen neurologischen Erkrankungen wie Pure Autonomic Failure oder Multisystematrophie können zunächst kardiovaskuläre Symptome wie orthostatische Kreislaufstörungen oder Herzfrequenzschwankungen mit symptomatischer ...
C. Haubrich, T. Klingenheben
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031 Pelvic autonomic dysfunction is common in patients with pure autonomic failure
Journal of Neurology Neurosurgery & Psychiatry, 2022Introduction Cardiovascular autonomic failure is the hallmark finding in Pure autonomic failure (PAF) however other autonomic functions are likely to be affected. This study aims to characterise genitourinary dysfunction in PAF patients and explore their
E. Vichayanrat +5 more
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2013
A 1925 report by Bradbury and Eggleston first described patients with extreme orthostatic hypotension and a low, steady heart rate. Evidence accumulated over the next two decades that patients with orthostatic hypotension include those with pure autonomic failure (PAF), characterized by isolated peripheral autonomic dysfunction and decreased ...
Emily M, Garland +2 more
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A 1925 report by Bradbury and Eggleston first described patients with extreme orthostatic hypotension and a low, steady heart rate. Evidence accumulated over the next two decades that patients with orthostatic hypotension include those with pure autonomic failure (PAF), characterized by isolated peripheral autonomic dysfunction and decreased ...
Emily M, Garland +2 more
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Current Neurology and Neuroscience Reports, 2016
Pure autonomic failure (PAF) is a rare sporadic neurodegenerative autonomic disorder characterized by slowly progressive pan autonomic failure without other features of neurologic dysfunctions. The main clinical symptoms result from neurogenic orthostatic hypotension and urinary and gastrointestinal autonomic dysfunctions.
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Pure autonomic failure (PAF) is a rare sporadic neurodegenerative autonomic disorder characterized by slowly progressive pan autonomic failure without other features of neurologic dysfunctions. The main clinical symptoms result from neurogenic orthostatic hypotension and urinary and gastrointestinal autonomic dysfunctions.
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Hyposmia in pure autonomic failure
Neurology, 2009Parkinson disease (PD), multiple system atrophy (MSA), and pure autonomic failure (PAF) all present with varying degrees of dysautonomia and are pathologically characterized by accumulation of alpha-synuclein. Hyposmia and olfactory pathway pathology are found in PD and MSA. We tested odor identification in 16 patients with PAF and compared the results
L, Silveira-Moriyama +5 more
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Pure autonomic failure without synucleinopathy
Clinical Autonomic Research, 2017Pure autonomic failure is a rare form of chronic autonomic failure manifesting with neurogenic orthostatic hypotension and evidence of sympathetic noradrenergic denervation unaccompanied by signs of central neurodegeneration. It has been proposed that pure autonomic failure is a Lewy body disease characterized by intra-neuronal deposition of the ...
Risa, Isonaka +5 more
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Neurology and Clinical Neuroscience, 2021
Pure autonomic failure (PAF) and multiple system atrophy (MSA) are representative neurodegerative diseases present with a severe autonomic dysfunction in the urinary, cardiovascular, and pupillary systems, as well as the gastrointestinal tract and skin ...
Y. Yamanaka, N. Araki, S. Kuwabara
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Pure autonomic failure (PAF) and multiple system atrophy (MSA) are representative neurodegerative diseases present with a severe autonomic dysfunction in the urinary, cardiovascular, and pupillary systems, as well as the gastrointestinal tract and skin ...
Y. Yamanaka, N. Araki, S. Kuwabara
semanticscholar +1 more source
Practical Neurology, 2017
Pure autonomic failure is a degenerative disorder of the peripheral autonomic nervous system. Patients experience symptomatic hypotension that requires them to sit, squat or lie down to prevent syncope. It is associated with characteristic histopathological findings, resulting in neuronal cytoplasmic inclusions in the peripheral autonomic nerves. These
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Pure autonomic failure is a degenerative disorder of the peripheral autonomic nervous system. Patients experience symptomatic hypotension that requires them to sit, squat or lie down to prevent syncope. It is associated with characteristic histopathological findings, resulting in neuronal cytoplasmic inclusions in the peripheral autonomic nerves. These
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Micturitional disturbance in pure autonomic failure
Neurology, 2000We obtained micturitional histories and performed urodynamic studies in six patients with pure autonomic failure. All patients had urinary symptoms. Urodynamic studies showed postmicturition residuals in two, small bladder capacities in two, detrusor hyperreflexia in four, low bladder compliance in two, detrusor-external sphincter dyssynergia in one ...
R, Sakakibara +4 more
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