Results 151 to 160 of about 26,782 (262)

Transient modeling of extraction columns: Parameter estimation, uncertainty analysis, and operation optimization

open access: yesAIChE Journal, EarlyView.
Abstract Despite extensive modeling efforts in extraction research, transient column models are rarely applied in industry due to concerns regarding parameter identifiability and model reliability. To address this, we analyzed uncertainty propagation from estimated parameters in a previously introduced column model and assessed identifiability via ill ...
Andreas Palmtag   +2 more
wiley   +1 more source

Textural Properties of Carbopol® Gel with Curcumin and Curcumin-HPβCD Inclusion Complex and Biological Activities. [PDF]

open access: yesGels
Urošević M   +7 more
europepmc   +1 more source

Hybrid modeling for optimizing cell cultivation in mAb production using a small‐scale automated experimental platform

open access: yesAIChE Journal, EarlyView.
Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto   +6 more
wiley   +1 more source

Trust‐region filter algorithms utilizing Hessian information for gray‐box optimization

open access: yesAIChE Journal, EarlyView.
Abstract Optimizing industrial processes often involves gray‐box models that couple algebraic glass‐box equations with black‐box components lacking analytic derivatives. Such systems challenge derivative‐based solvers. The classical trust‐region filter (TRF) algorithm provides a robust framework but requires extensive parameter tuning and numerous ...
Gul Hameed   +4 more
wiley   +1 more source

A trust‐region funnel algorithm for gray‐box optimization

open access: yesAIChE Journal, EarlyView.
Abstract Gray‐box optimization, where parts of optimization problems are represented by algebraic models while others are treated as black‐box models lacking analytic derivatives, remains a challenge. Trust‐region (TR) methods provide a robust framework for gray‐box problems through local reduced models (RMs) for black‐box components, but they are ...
Gul Hameed   +4 more
wiley   +1 more source

Spheres, tears, and spears: Regulating the perimeter and circularity of millimeter‐sized alginate hydrogel beads

open access: yesAIChE Journal, EarlyView.
Abstract Generating hydrogel beads pertains to many engineering applications. We examined two alginate‐based fluids at three concentrations of alginate, cAG$$ {c}_{\mathrm{AG}} $$. We used the “Map of Misery” to determine which material property (viscosity, elasticity, and inertia) drives droplet formation.
Conor G. Harris   +5 more
wiley   +1 more source

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