Results 261 to 270 of about 3,238,502 (335)

Engineering Adenine Deaminase TadA for Precise and PAM‐Flexible Point Mutagenesis and Gradient‐Tuning Endogenous Protein Design

Advanced Science, EarlyView.
Base editing enables precise nucleotide substitutions but limited by bystander editing. This study engineers plant base editors by fusing optimized TadA variants with PAM‐flexible SpRY nickase, enabling A‐to‐G, C‐to‐T, and dual‐base conversions in a highly condensed window (≤3 nucleotides). Additionally, TadDBE (TadA Dual‐Base Editor)‐mediated directed
Kangli Sun, Si Cheng, Nan Chai, Jianing Mi, Ruixiang Zhang, Qian Qian, Zhiye Zheng, Ke Chen, Dongchang Zeng, Xin Peng, Mengyuan Shen, Degui Zhou, Qinlong Zhu, Qi Liu, Jiantao Tan   +14 more
wiley   +1 more source

Coherent manipulation of Goos-Hänchen shifts by forward and backward currents of complex conductivity in chiral medium. [PDF]

Sci Rep
Ul Haq Z, Ahmad I, Bacha BA, Akgül A, Hassani MK.   +4 more
europepmc   +1 more source

Wide Linearity Range and Rapid‐Response Tactile Sensor Inspired by Parallel Structures

Advanced Science, EarlyView.
Inspired by parallel structures, a composite tactile sensor design is proposed using parallel elastomer integration, developing two novel sensors. This strategy optimizes the force‐electric response and viscoelastic hysteresis of the conductive composite, achieving a balanced enhancement of linear sensing range and fast response.
Weihua Gao, Jiantao Yao, Xianhe Yu, Guoliang Ma, Dakai Wang, Hongnian Yu, Zhiwu Han, Luquan Ren   +7 more
wiley   +1 more source

A new iterative multi-step method for solving nonlinear equation. [PDF]

MethodsX
Usman M, Iqbal J, Khan A, Ullah I, Khan H, Alzabut J, Alkhawar HM.   +6 more
europepmc   +1 more source

AI‐Driven De Novo Design of Ultra Long‐Acting GLP‐1 Receptor Agonists

Advanced Science, EarlyView.
De novo GLP‐1RAs can be computationally designed to exhibit extended half‐life and superior efficacy compared to Semaglutide. Abstract Peptide drugs have revolutionized modern therapeutics, offering novel treatment avenues for various diseases. Nevertheless, low design efficacy, time consumption, and high cost still hinder peptide drug design and ...
Ting Wei, Jiating Ma, Xiaochen Cui, Jiahui Lin, Zhuoqi Zheng, Liu Cheng, Taiying Cui, Xiaoqian Lin, Junjie Zhu, Xuyang Ran, Xiaokun Hong, Luke Johnston, Zhangsheng Yu, Haifeng Chen   +13 more
wiley   +1 more source

A ϱ -Weyl fractional operator of the extended S -type function in a complex domain. [PDF]

MethodsX
Hadi SH, Challab KA, Ali AH, Alatawi AA.
europepmc   +1 more source

Winners of the 2012 JMAA Ames Awards in pure and applied mathematics

, 2013
Richard M. Aron, Goong Chen, Steven G. Krantz, Laura Schmidt   +3 more
openalex   +1 more source

Topological Singularities and Edge‐State Coupling Enable Robust on‐Chip Slow Light

Advanced Science, EarlyView.
This work demonstrates the first experimental observation of a topological quantum‐interference‐like effect in a 1D on‐chip system, utilizing two topological mechanisms for robust slow light. Topological charges ensure immunity to parameter deviations, while edge states provide robustness against disturbances.
Yuqian Wang, Shengyu Hu, Zhiwei Guo, Jie Jiang, Yaping Yang, Cuicui Lu, Hong Chen   +6 more
wiley   +1 more source

A simple mathematical model for evaluation of non-fragmentation property of injectable calcium-phosphate cement. [PDF]

Sci Rep
Ichida Y, Yamada R, Kato S, Kamaya Y, Kosuge M, Aizawa M, Sakamoto TO, Yazaki S.   +7 more
europepmc   +1 more source

Molecularly Engineered Hydrogel Electrolyte Embedded with Multifunctional Oxygen‐Rich Macrocyclic Units for Uniform Zinc Deposition

Advanced Science, EarlyView.
A multifunctional monomer, benzo‐15‐crown‐5‐acrylamide (BCAm) is designed, and the P(BCAm‐co‐AM) hydrogel electrolyte (PBCM‐HE) is prepared. This design not only enhances mechanical properties by rigid‐flexible hybrid structure, but also adjusts solvation sheath structure for stable electrolyte‐Zn anode interface.
Miao Sun, Guochen Ji, Meizhi Li, Junping Zheng   +3 more
wiley   +1 more source