Results 61 to 70 of about 445,186 (328)
Functional magnetic resonance imaging measurements of sound-level encoding in the absence of background scanner noise [PDF]
, 2002 Effects of sound level on auditory cortical activation are seen in neuroimaging data. However, factors such as the cortical response to the intense ambient scanner noise and to the bandwidth of the acoustic stimuli will both confound precise ...
Akeroyd, MA +5 more
core +1 more source
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Bioacustics of Hylarana Celebensis (Peters, 1872) (Anura: Ranidae)From Sulawesi [PDF]
, 2016 Hylarana celebensis (Peters, 1872) is an endemic frog to Sulawesi, the species being a member of family Ranidae. The presence of the frog in its habitat is easily detected from its advertisement call; males usually call in a chorus, they call to each ...
Kurniati, H. (Hellen)
core
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Tone burst sensitivity in normal and sensorineural hearing impaired listeners [PDF]
, 1982 This paper discusses a study to predict the pure tone audiogram from the results of electric response audiometry utilizing frequency-selective tone burst ...
Solecki, Janet M
core +1 more source
Multilayer Spiking Neural Network for Audio Samples Classification Using SpiNNaker [PDF]
, 2016 Audio classification has always been an interesting subject of research inside the neuromorphic engineering field. Tools like Nengo or Brian, and hardware platforms like the SpiNNaker board are rapidly increasing in popularity in the neuromorphic ...
Cerezuela Escudero, Elena +6 more
core +1 more source
A directly comparative two-gate case–control diagnostic accuracy study of the pure tone screen and HearCheck screener tests for identifying hearing impairment in school children [PDF]
, 2017 Objectives: This study directly compared the accuracy of two audiometry-based tests for screening school children for hearing impairment: the currently used test, pure tone screen and a device newly applied to children, HearCheck Screener. Design: Two-
Benton, Claire +10 more
core +5 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management
Molecular Oncology, EarlyView.DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez +5 more
wiley +1 more source