Results 61 to 70 of about 6,421 (229)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Oak Ridge National Laboratory Report CF-57-6-17 [PDF]

, 1957
Measurements of flow rate through the fuel high-pressure system sampler indicate that the average flow rates is about 0.29 gpm (145 lb/hr) plus or minus 50%, which affords an adequate purge of from 12 to 36 volumes through the sample line if the full ...
Van Winkle, R., Wiethaup, R. R.
core  

Removal of Impurity Elements from Molten Aluminum: a Review [PDF]

, 2011
In the current paper, the technical progress of aluminum refining over the past 30 years has been summarized, including the improvement of batch reactor and in-line continuous reactors, the evolution of gas purging methods by nozzle, porous plug, and ...
Lifeng Zhang, Xuewei Lv, Long, Mujun, Torgerson, Alex Tryg, Zhang, Lifeng, Alex Tryg Torgerson, Mujun Long, Lv, Xuewei   +7 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Preliminary results from the testing of an advanced passive solar still incorporating a shielded condenser [PDF]

, 2008
An advanced passive solar still with separate condenser has been studied theoretically and experimentally. The system has one basin in the evaporation chamber and two basins (middle and upper) in the condenser chamber, with a glass cover over the ...
Madhlopa, Amos, Johnstone, Cameron, Madhlopa, A., Johnstone, C.M.   +3 more
core  

Outlook for potential third-generation immersion fluids [PDF]

, 2007
In a search for alkane candidates for 193 nm immersion fluids, several alkanes and cycloalkanes were synthesized, purified and screened to ascertain their absorption at 193 nm, refractive index and temperature dispersion coefficient in the context of the
Paul Zimmerman, López-Gejo, Juan, Smith, Bruce W., Nicholas J. Turro, J. Zhou, Turro, Nicholas J., Zhou, J., Zimmerman, Paul, Will Conley, B. W. Smith, Kunjappu, Joy T., Joy T. Kunjappu, Conley, Will, Juan López-Gejo   +13 more
core   +2 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Evaluación de la purga genética en poblaciones de censo reducido [PDF]

, 2017
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Ciencias Biológicas, Departamento de Genética, leída el 11-05-2017La depresión consanguínea puede ser decisiva para la extinción de poblaciones de censopequeño.
López Cortegano, Eugenio
core   +1 more source