Results 51 to 60 of about 148,305 (130)

Kinetic Modelling and Inference of Hyperpolarized 13C Molecules in Cancer Metabolism [PDF]

arXiv, 2017
Hyperpolarized 13C-MRI allows real time observation of metabolism in vivo. Imaging sequences have been developed to follow the metabolism of [1-13C] pyruvate and extract reaction kinetics, which can show tumour treatment response. We applied the fitting model and algorithm for the imaging data of mice tumour models and determined error estimates for ...
arxiv  

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

Metabolic blood profile and response to treatment with the pyruvate kinase activator mitapivat in patients with sickle cell disease [PDF]

Mitapivat is an investigational, oral, small-molecule allosteric activator of pyruvate kinase (PK). PK is a regulatory glycolytic enzyme that is key in providing the red blood cell (RBC) with sufficient amounts of adenosine triphosphate (ATP).
Bartels, Marije, Biemond, Bart J., Bos, Jennifer, Cnossen, Marjon H., Derichs, Cleo, Jans, Judith J.M., Nur, Erfan, Rab, Minke A.E., Rijneveld, Anita W., Ruiter, Titine J.J., Schutgens, Roger E.G., van Beers, Eduard J., van der Veen, Sigrid, van Dijk, Myrthe J., van Oirschot, Brigitte A., van Solinge, Wouter W., van Wijk, Richard   +16 more
core   +4 more sources

In silico experimentation with a model of hepatic mitochondrial folate metabolism [PDF]

, 2006
BACKGROUND: In eukaryotes, folate metabolism is compartmentalized and occurs in both the cytosol and the mitochondria. The function of this compartmentalization and the great changes that occur in the mitochondrial compartment during embryonic ...
Gregory, Jesse F, Lam, Shi-Ling, Nijhout, H Frederik, Reed, Michael C, Shane, Barry, Ulrich, Cornelia M   +5 more
core   +3 more sources

A new case of sodium‐dependent multivitamin transporter defect occurring as a life‐threatening condition responsive to early vitamin supplementation and literature review

Molecular Genetics &Genomic Medicine, Volume 12, Issue 2, February 2024.
We highlight the life‐threatening presentation of SMVT deficiency. Increased and isolated excretion of urinary 3‐hydroxyisovaleric acid may suggest, in the absence of markedly reduced biotinidase activity, a SMVT deficiency. Prompt supplementation with high doses of biotin and pantothenic acid should be initiated while awaiting results of SLC5A6 ...
F.‐X. Van Vyve, N. Mercier, J. Papadopoulos, C. Heijmans, H. Dessy, O. Monestier, J. P. Dewulf, D. Roland   +7 more
wiley   +1 more source

Models of Innate Neural Attractors and Their Applications for Neural Information Processing [PDF]

arXiv, 2015
In this work we reveal and explore a new class of attractor neural networks, based on inborn connections provided by model molecular markers, the molecular marker based attractor neural networks (MMBANN). We have explored conditions for the existence of attractor states, critical relations between their parameters and the spectrum of single neuron ...
arxiv  

Selective vulnerability of hippocampal CA1 and CA3 pyramidal cells: What are possible pathomechanisms and should more attention be paid to the CA3 region in future studies?

Journal of Neuroscience Research, Volume 102, Issue 1, January 2024.
Our collecting data give an overview of damage expression in hippocampal CA1 and CA3 regions after ischemia/reperfusion, demonstrating a stronger damage of CA3 neurons than previously assumed. These findings with discussion of possible pathomechanisms contributing to selective vulnerability indicate that future studies should additionally focus on CA3.
Anne‐Marie Einenkel, Aida Salameh
wiley   +1 more source

Red herrings and rotten fish [PDF]

arXiv, 2002
A longstanding problem in biology has been the origin of pervasive quarter-power allometric scaling laws that relate many characteristics of organisms to body mass (M) across the entire spectrum of life from molecules and microbes to ecosystems and mammals. In particular, whole-organism metabolic rate, B=aM^b, where a is a taxon-dependent normalisation
arxiv  

A Minimal Power Model for Human Running Performance [PDF]

, 2018
Models for human running performances of various complexities and underlying principles have been proposed, often combining data from world record performances and bio-energetic facts of human physiology. Here we present a novel, minimal and universal model for human running performance that employs a relative metabolic power scale.
arxiv   +1 more source

Severe Megaloblastic Anaemia in an Infant [PDF]

, 2011
Vitamin B 12 or cobalamin deficiency, a rare clinical entity in pediatric age, is found most exclusively in breastfed infants, whose mothers are strictly vegetarian non-supplemented or with pernicious anaemia.
Brito, MJ, Cordeiro Ferreira, G, Dias, A, Galvão, I, Rodrigues, V   +4 more
core   +2 more sources