Genotype networks, innovation, and robustness in sulfur metabolism [PDF]
arXiv, 2010 Metabolic networks are complex systems that comprise hundreds of chemical reactions which synthesize biomass molecules from chemicals in an organism's environment. The metabolic network of any one organism is encoded by a metabolic genotype, defined by a set of enzyme-coding genes whose products catalyze the network's reactions. Each metabolic genotype
arxiv
Should Metabolic Diseases Be Systematically Screened in Nonsyndromic Autism Spectrum Disorders? [PDF]
, 2020 Background: In the investigation of autism spectrum disorders (ASD), a genetic cause is found in approximately 10-20%. Among these cases, the prevalence of the rare inherited metabolic disorders (IMD) is unknown and poorly evaluated.
Hé Lè Ne Ogier De Baulny +6 more
core
Critical dynamics of gene networks is a mechanism behind ageing and Gompertz law [PDF]
arXiv, 2015 Although accumulation of molecular damage is suggested to be an important molecular mechanism of aging, a quantitative link between the dynamics of damage accumulation and mortality of species has so far remained elusive. To address this question, we examine stability properties of a generic gene regulatory network (GRN) and demonstrate that many ...
arxiv
Topological Quantum Computation and Error Correction by Biological Cells [PDF]
arXiv, 2005 A Topological examination of phospholipid dynamics in the Far from Equilibrium state has demonstrated that metabolically active cells use waste heat to generate spatially patterned membrane flows by forced convection and shear. This paper explains the resemblance between this nonlinear membrane model and Witten Kitaev type Topological Quantum ...
arxiv
From Lab to Wrist: Bridging Metabolic Monitoring and Consumer Wearables for Heart Rate and Oxygen Consumption Modeling [PDF]
arXivUnderstanding physiological responses during running is critical for performance optimization, tailored training prescriptions, and athlete health management. We introduce a comprehensive framework -- what we believe to be the first capable of predicting instantaneous oxygen consumption (VO$_{2}$) trajectories exclusively from consumer-grade wearable ...
arxiv
PET Quantification of Ultra Low Activity via Inhomogeneous Poisson Process Parameters Estimation Directly from Listmode Data [PDF]
arXiv, 2019 Metabolic imaging with PET/CT using $^{18}$F-Fludeoxyglucose ($^{18}$F-FDG) as well as other imaging biomarkers has achieved wide acceptance in oncology, cardiology and neurology not only because of the unique metabolic information generated by this modality, but also because of its ability to quantify biological processes.
arxiv
UEG Week 2024 Moderated Posters
United European Gastroenterology Journal, Volume 12, Issue S8, Page 201-664, October 2024.
wiley +1 more source
Possible role for neopterin: control of purine metabolism [PDF]
, 1996 There is a marked increase in the level of neopterin in the plasma and urine of people under stress. Neopterin is an intermediate that is made during biopterin synthesis.
Ebong, Samuel John
core +1 more source
The many roads to dementia: a systems view of Alzheimer's disease [PDF]
arXivAlzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying metabolic collapse.
arxiv
Boolean matrix logic programming for active learning of gene functions in genome-scale metabolic network models [PDF]
arXivTechniques to autonomously drive research have been prominent in Computational Scientific Discovery, while Synthetic Biology is a field of science that focuses on designing and constructing new biological systems for useful purposes. Here we seek to apply logic-based machine learning techniques to facilitate cellular engineering and drive biological ...
arxiv