Results 21 to 30 of about 27,209 (247)

Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2-fluoro-cordycepin Synthesis [PDF]

Biomolecules, 2021
During the preparative synthesis of 2-fluorocordycepin from 2-fluoroadenosine and 3′-deoxyinosine catalyzed by E. coli purine nucleoside phosphorylase, a slowdown of the reaction and decrease of yield down to 5% were encountered.
Alexey L. Kayushin, Julia A. Tokunova, Ilja V. Fateev, Alexandra O. Arnautova, Maria Ya. Berzina, Alexander S. Paramonov, Olga I. Lutonina, Elena V. Dorofeeva, Konstantin V. Antonov, Roman S. Esipov, Igor A. Mikhailopulo, Anatoly I. Miroshnikov, Irina D. Konstantinova   +12 more
doaj   +2 more sources

Multistep loss of catalytic and ligand binding abilities of hexameric purine nucleoside phosphorylase [PDF]

Scientific Reports
It is commonly believed that enzymatic catalysis is such a complex process, that even a small change in any physicochemical property of the enzyme results in a complete loss of the catalytic and ligand-binding capacity of the molecule.
Marta Narczyk, Agnieszka Bzowska
doaj   +2 more sources

Purine nucleoside phosphorylase targeted by annexin v to breast cancer vasculature for enzyme prodrug therapy. [PDF]

PLoS ONE, 2013
BACKGROUND AND PURPOSE: The targeting of therapeutics is a promising approach for the development of new cancer treatments that seek to reduce the devastating side effects caused by the systemic administration of current drugs.
John J Krais, Olivier De Crescenzo, Roger G Harrison   +2 more
doaj   +2 more sources

Immunodeficiency, motor delay, and hypouricemia caused by a novel mutation of purine nucleoside phosphorylase gene in an Indian infant [PDF]

Annals of Indian Academy of Neurology, 2019
We describe an 11-month-old boy who presented with recurrent respiratory infections from 6 months of age. His elder sister died at 10 months with severe septicemia and meningitis. The boy had a mild motor delay.
Nikit Shah, Lokesh Lingappa, Ramesh Konanki, Sirisha Rani, Ramprasad Vedam, Sakthivel Murugan   +5 more
doaj   +2 more sources

Purine Nucleoside Phosphorylase [PDF]

Catalysis from A to Z, 2020
semanticscholar   +3 more sources

Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum. [PDF]

Proc Natl Acad Sci U S A, 2018
Ducati RG, Namanja-Magliano HA, Harijan RK, Fajardo JE, Fiser A, Daily JP, Schramm VL.   +6 more
europepmc   +2 more sources

Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice. [PDF]

J Cell Mol Med
ABSTRACT Red blood cells (RBCs) contain the highest purine nucleoside phosphorylase (PNP) level per cell volume, yet the role of PNP in the pathogenesis of sickle cell disease (SCD) is incompletely understood, highlighting an important gap in our knowledge of the disease.
Alagbe AE, Little-Ihrig L, Mutchler SM, Jackson EK, Novelli EM, Tofovic SP.   +5 more
europepmc   +2 more sources

Cloning and expression of recombinant purine nucleoside phosphorylase in the methylotrophic yeast Pichia pastoris

Journal of Advanced Biotechnology and Experimental Therapeutics, 2023
Purine Nucleoside Phosphorylase (PNP) is an enzyme involved in biosynthetic pathway of purine nucleosides. Purine nucleoside phosphorylase catalyzes the cleavage of the glycosidic bond of ribo- or deoxyribonucleosides to form the purine base and ...
Jaloliddin Abdurakhmanov, Sobirdjan Sasmakov, Shukhrat Khasanov, Oybek Ashirov, Farkhod Eshboev, Khayotjon Dolimov, Saodat Gaynazarova, Tulkin Sadullaev, Oygul Yarilkaganova, Khusan Nasriddinov, Asadali Baymirzaev, Artyom Makhnyov, Shakhnoz Azimova   +12 more
doaj   +1 more source

Phase I dose-escalating trial of Escherichia coli purine nucleoside phosphorylase and fludarabine gene therapy for advanced solid tumors.

Annals of Oncology, 2015
E. Rosenthal, Thomas K Chung, W. Parker, P. Allan, L. Clemons, Deborah Lowman, J. Hong, F. R. Hunt, J. Richman, R. Conry, K. Mannion, W. Carroll, L. Nabell, E. Sorscher   +13 more
semanticscholar   +3 more sources

Investigating the Vital Role of the Identified Abietic Acid from Helianthus annuus L. Calathide Extract against Hyperuricemia via Human Embryonic Kidney 293T Cell Model

Molecules, 2023
To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60 µM ...
Huining Dai, Xiao Xu, Wannan Li, Xueqi Fu, Weiwei Han, Guodong Li   +5 more
doaj   +1 more source