Results 111 to 120 of about 13,838 (206)

N-body Information Theory (NbIT) Analysis of Rigid-Body Dynamics in Intracellular Loop 2 of the 5-HT2A Receptor [PDF]

arXiv, 2014
Rigid-body motions of protein secondary structure are often implicated in mecha-nisms of protein function. In GPCRs, evidence suggests that intracellular loop 2 (IL2) contains a segment characterized as a helix when the activated receptor trig-gers downstream signaling.
arxiv  

Utilizing AI and Social Media Analytics to Discover Adverse Side Effects of GLP-1 Receptor Agonists [PDF]

arXiv
Adverse side effects (ASEs) of drugs, revealed after FDA approval, pose a threat to patient safety. To promptly detect overlooked ASEs, we developed a digital health methodology capable of analyzing massive public data from social media, published clinical research, manufacturers' reports, and ChatGPT.
arxiv  

Nucleotide P2Y1 receptor agonists are in vitro and in vivo prodrugs of A1/A3 adenosine receptor agonists: implications for roles of P2Y1 and A1/A3 receptors in physiology and pathology

Purinergic Signalling Purinergic Signalling, 2020
T. Liston, Sonja Hinz, C. Müller, D. Holstein, J. Wendling, R. Melton, Mary Campbell, William S. Korinek, R. Suresh, Dane A. Sethre-Hofstad, Zhang-Guo Gao, D. Tosh, K. Jacobson, J. Lechleiter   +13 more
semanticscholar   +1 more source

Discrimination vs. Generation: The Machine Learning Dichotomy for Dopaminergic Hit Discovery [PDF]

arXiv
Virtual screening plays a pivotal role in early drug discovery, traditionally dominated by physics-based methods. While these approaches offer detailed insights, they are often hindered by high computational costs, limited sampling, and forcefield inaccuracies.
arxiv  

Individual sympathetic varicosities possess different sensitivities to alpha 2 and P2 receptor agonists and antagonists in mouse vas deferens

British Journal of Pharmacology, 1999
S. O'Connor, K. Brain, M. R. Bennett
semanticscholar   +1 more source

P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. [PDF]

, 2012
The P2X7 receptor is an ATP-gated non-selective cation-permeable ionotropic receptor selectively expressed in neurons and glia in the brain. Activation of the P2X7 receptor has been found to modulate neuronal excitability in the hippocampus and it has ...
Diaz-Hernandez, Miguel, Engel, Tobias, Henshall, David C, Jimenez-Pacheco, Alba, Miras-Portugal, Maria Teresa   +4 more
core   +2 more sources

Purinergic signalling is required for calcium oscillations in migratory chondrogenic progenitor cells [PDF]

, 2017
Csernoch, László, Fodor, János, Juhász, Tamás, Matta, Csaba, Miosge, Nicolai, Rybaltovszki, Henrik, Takács, Roland Ádám, Tóth, Adrienn, Zákány, Róza   +8 more
core   +1 more source

Integrating computational detection and experimental validation for rapid GFRAL-specific antibody discovery [PDF]

arXiv
The identification and validation of therapeutic antibodies is critical for developing effective treatments for many diseases. We present a computational approach for identifying antibodies targeting GFRAL-specific receptors, receptors implicated in appetite regulation. Using humanized Trianni mice, we conducted a longitudinal study with repeated blood
arxiv  

Development of a comprehensive set of P2 receptor pharmacological research compounds

Purinergic Signalling Purinergic Signalling, 2011
R. Felix, S. Martin, S. Pinion, D. J. Crawford   +3 more
semanticscholar   +1 more source

Extracellular ATP Neurotransmission and Nicotine Sex-Specifically Modulate Habenular Neuronal Activity in Adolescence. [PDF]

J Neurosci, 2023
Chen YC, Rindner DJ, Fowler JP, Lallai V, Mogul A, Demuro A, Lur G, Fowler CD.   +7 more
europepmc   +1 more source