School uniforms, religious, symbols and the Human Rights Act 1998: the 'purity ring' case
The paper comments on the decision of the High Court in R (Playfoot) v Governing Body of Millais School (the ‘purity ring’ case), where the court was asked to rule on whether the school’s governing body’s decision not to allow Lydia Playfoot to wear a ...
Bacquet, S.
core
Evaluating the influence of different anticoagulant blood collection tubes on the efficiency of circulating RNA extraction and Real-Time PCR quantification. [PDF]
Di Ruvo M +8 more
europepmc +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Improvement of precise large-fragment deletion with a versatile nuclease prime editor. [PDF]
Li X +12 more
europepmc +1 more source
CEACAM1 participation in breast cancer progression
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
3D printing of high‐purity silicon carbide
K. Terrani, B. Jolly, M. Trammell
semanticscholar +1 more source
Discovery of new diaminoquinazolines against <i>Mycobacterium tuberculosis</i>: chemical synthesis and <i>in vitro</i> evaluation. [PDF]
Kore M +4 more
europepmc +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
A Rapid Poly(ethylene glycol)-Assisted Magnetic Isolation Approach for High-Throughput Extracellular Vesicle Isolation and Subsequent Biomarker Analysis. [PDF]
Sun L +9 more
europepmc +1 more source

