Results 151 to 160 of about 8,942,088 (298)

Reconceptualizing Purpose in the Third Age: From Linear Accumulation to Present-Centred Sufficiency? [PDF]

Psychol Res Behav Manag
Han J.
europepmc   +1 more source

On the role of general purpose technologies within the Marshall-Jacobs controversy: The case of nanotechnologies [PDF]

This paper investigates the role of nanotechnologies as a general purpose technology for regional development. Due to pervasiveness, nanotechnologies may be utilized in diverse applications thereby providing the basis for both localization and ...
Ott, Ingrid, Menz, Nina
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

When are large language models medical devices? Navigating the MDR and AI Act for healthcare applications. [PDF]

BMJ Digit Health Ai
Workum JD, Krijgsman SJ, Vajda I, Van Stokkum RM, van de Brand J, Gommers D, Ercole A, van Genderen M.   +7 more
europepmc   +1 more source

Dynamics of General Purpose Technologies in an Open Economy [PDF]

While the Helpman-Trajtenberg model is successful in explaining the macroeconomic cycle generated by GPT in the context of a closed economy, open-economy implications regarding GPT have received scant attention.
Chung, Jaiho, Hwang, Joon Ho
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The evidential role of economic models in legal proceedings. [PDF]

Eur J Philos Sci
Peruzzi E.
europepmc   +1 more source

Creative purpose [PDF]

Epidemiology and Psychiatric Sciences, 2020
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source