Results 191 to 200 of about 3,020,168 (266)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Macro Monte Carlo dose calculation for very high energy electron (VHEE) radiotherapy. [PDF]

Med Phys
Zhu C, Amstutz F, Costantini CM, Volken W, Stampanoni MFM, Manser P, Fix MK.   +6 more
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A user behavior inertia based spatio temporal next POI recommendation model. [PDF]

Sci Rep
Zhang K, Chu D, Tu Z, Hong Z.
europepmc   +1 more source

Comparison of artificial intelligence and rheumatologists in nailfold capillaroscopic evaluation. [PDF]

Rev Assoc Med Bras (1992)
Çelik NÇ, Kılınç EA.
europepmc   +1 more source

"HER2-Low" and the Challenge of Repurposing Legacy HER2 IHC Biomarker Assays. [PDF]

Curr Oncol
Torlakovic EE, Gown AM.
europepmc   +1 more source

Psychometric properties of the purpose in life scale in Peruvian university students. [PDF]

Front Psychol
Vilca-Pareja V, Ardiles-Irarrázabal RA, Hillpa-Zuñiga ME, Yana-Calla VR.   +3 more
europepmc   +1 more source

Productive and Reproductive Record Keeping in Low-to-Middle-Income Tropical Livestock Systems: Challenges and Perspectives. [PDF]

Animals (Basel)
Romero-Zúñiga JJ, Galina CS, Geffroy M, Corro MD, Maquivar M.   +4 more
europepmc   +1 more source