Results 91 to 100 of about 5,862,696 (348)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
The relationship between the purpose in life and general health in Veterans and ordinary people
طب جانباز, 2013 Background: Purpose and meaning of life is most important issues of religious, administrative, philosophical and psychological. Having meaning and purpose in life indicate mental health and cause to increase ability to do things. Purpose: This research
M. Mahbobi +4 more
doaj
GeriatricsBackground/Objectives: Research suggests that attitudes toward aging significantly impact health and well-being outcomes in older adults and are influenced by various factors.
Muna Bhattarai +2 more
doaj +1 more source
BOOK REVIEW OF THE HAPPINESS PROJECT WRITTEN BY GRETCHEN RUBIN [PDF]
, 2016 This book review analyzes the strengths and weaknesses of Gretchen Rubin’s The Happiness Project. The Happiness Project is a novel about how to pursuit happiness in life.
Prasetyo, Mochammad Afrizal
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Wittgenstein and Maimonides on God and the Limits of Language [PDF]
, 2011 The purpose of this paper is to bring together two thinkers that are concerned with the limits of what can be said, Wittgenstein and Maimonides, and to explore the sense of the good life and of the mystical to which their therapeutic linguistic work ...
Verbin, N.
core +1 more source
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Sustainability as a life purpose among first-semester students at a private university in Malaysia
Discover SustainabilityIn response to the global sustainability crisis, education for sustainable development has become a pressing priority for universities in emerging nations, but nurturing students’ commitment to sustainability remains a challenge.
Lok Boon Thian +3 more
doaj +1 more source
RefugeThis longitudinal study examines trust in institutions among young refugees in Germany. Due to the scarcity of data, an initial exploratory approach was applied and the extent of trust in institutions is described; this is followed by a description of ...
Daniel Engel
doaj +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source