Results 111 to 120 of about 198,351 (337)

Pathologic manifestations of levamisole-adulterated cocaine exposure. [PDF]

, 2015
UnlabelledRheumatic manifestations of cocaine have been well described, but more recently, a dramatic increase in the levamisole-adulterated cocaine supply in the United States has disclosed unique pathologic consequences that are distinct from pure ...
Jen, Kuang-Yu, Nolan, Amber L
core   +1 more source

Quantitative Systems Pharmacology Modeling of Platelet Responses to Recombinant ADAMTS13 in Patients With Congenital Thrombotic Thrombocytopenic Purpura

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra‐rare, life‐threatening thrombotic microangiopathy caused by a severe inherited deficiency of ADAMTS13, a von Willebrand factor (VWF) cleaving enzyme. Inadequate clinical endpoint data often make it challenging to statistically power clinical trials in ultra‐rare diseases ...
Cameron McBride, Jiaolong Jiang, Zhiwei Zhang, John Tolsma, Parth Patwari, Björn Mellgård, Majid Vakilynejad, Indranil Bhattacharya, Andy Z. X. Zhu   +8 more
wiley   +1 more source

Preface to the special issue on: “Preclinical common data elements for epilepsy research part II of the TASK3 group of the ILAE/AES Joint Translational Task Force”

Epilepsia Open, EarlyView.
Aristea S. Galanopoulou
wiley   +1 more source

Optical Coherence Tomography Angiography in the Assessment of Vulvar Lichen Sclerosus Vascularity and Epithelial Thickness In Vivo

Translational Biophotonics, EarlyView.
Optical Coherence Tomography Angiography in the Assessment of Vulvar Lichen Sclerosus ABSTRACT Vulvar lichen sclerosus is a chronic inflammatory skin condition that leads to scarring and an increased risk of squamous cell carcinoma. It presents clinically as atrophic white patches or plaques, often with associated fissures, erosions, hyperkeratosis ...
Raksha Sreeramachandra Murthy, Christina N. Kraus, Felicia Lane, Zhongping Chen   +3 more
wiley   +1 more source

Aberrant Purkinje cell activity is the cause of dystonia in a shRNA-based mouse model of Rapid Onset Dystonia–Parkinsonism

Neurobiology of Disease, 2015
Loss-of-function mutations in the α3 isoform of the sodium pump are responsible for Rapid Onset Dystonia–Parkinsonism (RDP). A pharmacologic model of RDP replicates the most salient features of RDP, and implicates both the cerebellum and basal ganglia in
Rachel Fremont, Ambika Tewari, Kamran Khodakhah   +2 more
doaj  

Pediatric thrombotic thrombocytopenic purpura

European Journal of Haematology, 2018
Child‐onset thrombotic thrombocytopenic purpura (TTP) is a rare entity of thrombotic microangiopathy (TMA). The pathophysiology of the disease is based on a severe functional deficiency of ADAMTS13 (activity
B. Joly, P. Coppo, A. Veyradier
semanticscholar   +1 more source

Maximum Standard Uptake Value of Pre‐Therapeutic 18F‐Fluorodeoxyglucose Positron Emission Tomography Predicts Outcomes in Indolent Adult T‐Cell Leukemia/Lymphoma Patients With Cutaneous Involvement

The Journal of Dermatology, EarlyView.
ABSTRACT The prognostic utility of 18F‐fluorodeoxyglucose positron emission tomography (FDG‐PET) in adult T‐cell leukemia/lymphoma (ATLL) remains unclear, particularly in patients with indolent subtypes and cutaneous involvement. This study aimed to evaluate the usefulness of FDG‐PET in predicting clinical outcomes in patients with indolent ATLL ...
Kyoko Nogami, Yotaro Nishikawa, Kosuke Mochida, Tamasa Terada, Minako Azuma, Michikazu Nakai, Masahiro Amano   +6 more
wiley   +1 more source

Diagnosis and Management of Hypersensitivity to Antiplatelet Drugs: EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Antiplatelet drug (APD) therapy is the cornerstone for the prevention of atherosclerotic cardiovascular disease. The main APDs are aspirin and thienopyridines, particularly clopidogrel. These drugs may induce hypersensitivity reactions (HSRs).
Gabriele Cortellini, Alla Nakonechna, Annick Barbaud, Sevim Bavbek, Gianfranco Calogiuri, Inmaculada Doña, Violeta Kvedariene, Jose Julio Laguna Martinez, Serena Liberati, Mauro Pagani, Antonino Romano   +10 more
wiley   +1 more source

Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2017
Essentials Acquired thrombotic thrombocytopenic purpura (aTTP) is linked with significant morbidity/mortality. Caplacizumab's effect on major thromboembolic (TE) events, exacerbations and death was studied. Fewer caplacizumab‐treated patients had a major
F. Peyvandi, M. Scully, J. A. Hovinga, P. Knöbl, S. Cataland, K. D. Beuf, F. Callewaert, H. Winter, R. Zeldin   +8 more
semanticscholar   +1 more source

Increased plasma von Willebrand factor antigen levels but normal von Willebrand factor cleaving protease (ADAMTS13) activity in preeclampsia. [PDF]

, 2009
The activity of ADAMTS13, the von Willebrand factor (VWF) cleaving protease is low in several conditions, including HELLP (haemolysis, elevated liver enzymes, and low platelet count) syndrome.
Bõze, Tamás, Cervenak, László, Derzsy, Zoltán, Gombos, Tímea, Hársfalvi, Jolán, Makó, Veronika, Molvarec, Attila, Prohászka, Zoltán, Rigó, János, Udvardy, Miklós László   +9 more
core   +1 more source