Results 21 to 30 of about 77,124 (114)

The International Hereditary Thrombotic Thrombocytopenic Purpura Registry: key findings at enrollment until 2017

Haematologica, 2019
Congenital thrombotic thrombocytopenic purpura is an autosomal recessive inherited disease with a clinically heterogeneous course and an incompletely understood genotype-phenotype correlation.
H. A. van Dorland, M. M. Taleghani, K. Sakai, K. Friedman, J. George, I. Hrachovinova, P. Knöbl, A. von Krogh, R. Schneppenheim, I. Aebi-Huber, L. Bütikofer, C. Largiadèr, Z. Cermakova, K. Kokame, T. Miyata, H. Yagi, Deirdra R. Terrell, S. Vesely, M. Matsumoto, B. Lämmle, Y. Fujimura, J. K. Kremer Hovinga   +21 more
semanticscholar   +1 more source

Hereditary thrombotic thrombocytopenic purpura

Haematologica, 2019
The first description of thrombotic thrombocytopenic purpura (TTP) by Moschowitz was published nearly 100 years ago.[1][1] This was likely to have been an immune-mediated TTP episode and the author described multi organs affected with worsening ...
M. Scully
semanticscholar   +1 more source

Henoch-Schönlein Purpura: A Literature Review.

Acta Dermato-Venereologica, 2017
Henoch-Schönlein purpura is the most common childhood vasculitis, but may also affect adults. This article reviews the literature since 2011 on advances in diagnosis, clinical disease manifestations, pathophysiology and treatment of Henoch-Schönlein ...
L. Hetland, Kjærsti Sørensen Susrud, K. H. Lindahl, A. Bygum   +3 more
semanticscholar   +1 more source

Growth and morphogenesis of the gastropod shell

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Mollusc shells are emblematic of the morphological diversity in nature. They are important models for understanding the evolution of form; they are all variations on the same basic geometrical groundplan, their shapes can be directly related
Adam B. Johnson, Nina S. Fogel, J. Lambert   +2 more
semanticscholar   +1 more source

Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura

Haematologica, 2018
Immune-mediated thrombotic thrombocytopenic purpura is characterized by severe thrombocytopenia and microangiopathic hemolytic anemia. It is primarily caused by immunoglobin G type autoantibodies against ADAMTS13, a plasma metalloprotease that cleaves ...
E. Staley, W. Cao, H. Pham, Chong H. Kim, N. K. Kocher, Lucy Zheng, R. Gangaraju, Robin G. Lorenz, L. Williams, Marisa B. Marques, X. L. Zheng   +10 more
semanticscholar   +1 more source

Risk Factors Associated with Renal Involvement in Childhood Henoch-Schönlein Purpura: A Meta-Analysis

PLoS ONE, 2016
Background and objective Henoch-Schönlein purpura (HSP) is an important cause of chronic kidney disease in children. This meta-analysis identified risk factors associated with renal involvement in childhood HSP. Methods PubMed, Embase, and Web of Science
Han Chan, Yangzhang Tang, Xiaoyan Lv, Gaofeng Zhang, Mo Wang, Haiping Yang, Qiu Li   +6 more
semanticscholar   +1 more source

GABA as a Neurotransmitter in Gastropod Molluscs

The Biological Bulletin, 2019
The neurotransmitter gamma-aminobutyric acid (GABA) is widely distributed in the mammalian central nervous system, where it acts as a major mediator of synaptic inhibition.
Mark W. Miller
semanticscholar   +1 more source

Caplacizumab reduces the frequency of major thromboembolic events, exacerbations and death in patients with acquired thrombotic thrombocytopenic purpura

Journal of Thrombosis and Haemostasis, 2017
Essentials Acquired thrombotic thrombocytopenic purpura (aTTP) is linked with significant morbidity/mortality. Caplacizumab's effect on major thromboembolic (TE) events, exacerbations and death was studied. Fewer caplacizumab‐treated patients had a major
F. Peyvandi, M. Scully, J. A. Hovinga, P. Knöbl, S. Cataland, K. D. Beuf, F. Callewaert, H. Winter, R. Zeldin   +8 more
semanticscholar   +1 more source

Gastropod-derived haemocyte extracellular traps entrap metastrongyloid larval stages of Angiostrongylus vasorum, Aelurostrongylus abstrusus and Troglostrongylus brevior

Parasites & Vectors, 2017
BackgroundPhagocyte-derived extracellular traps (ETs) were recently demonstrated mainly in vertebrate hosts as an important effector mechanism against invading parasites.
M. Lange, F. Penagos-Tabares, T. Muñoz-Caro, U. Gärtner, H. Mejer, R. Schaper, C. Hermosilla, A. Taubert   +7 more
semanticscholar   +1 more source

Evolutionary norm-breaking and extinction in the marine tropics. [PDF]

Proc Natl Acad Sci U S A, 2023
Vermeij GJ.
europepmc   +1 more source