Results 101 to 110 of about 1,777,794 (293)
Scientific ReportsExcess water production is one of the challenges that can cause several operational and economic problems. In this work, a comprehensive study of the PPG swelling in the presence of monovalent and divalent ions was conducted.
Parviz Mehrabianfar +5 more
doaj +1 more source
Determining locations of sublacustrine springs by remote sensing: the Skadar Lake case example Montenegro [PDF]
Строительство уникальных зданий и сооружений, 2015 Locating zones of submarine or sublacustrine groundwater discharge often presents the most important part of a costal hydrogeological research. These zones are most commonly unobservable from the surface, so their determination requires complex ...
Milan Radulovic, Goran Sekulic
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Experimental Research of Continuous Concrete Beams with GFRP Reinforcement
Advances in Civil Engineering, 2018 Continuous beams are often used within RC structures, which are exposed to aggressive environmental impact. The use of the fiber-reinforced polymer (FRP) reinforcement in these objects and environments has a big significance, taking into account tendency
Nikola Baša +2 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Active dynamics and spatially coherent motion in chromosomes subject to enzymatic force dipoles
, 2019 Inspired by recent experiments on chromosomal dynamics, we introduce an exactly solvable model for the interaction between a flexible polymer and a set of motorlike enzymes. The enzymes can bind and unbind to specific sites of the polymer and produce a
PUT, Stefanie +2 more
core +1 more source