ABSTRACT Medicago sativa L. (alfalfa) harbors a remarkably diverse reservoir of bioactive secondary metabolites. Flavonoids, isoflavones, and triterpenoid saponins dominate its bioactivity landscape, driving potent antioxidant, anti‐inflammatory, antimicrobial, estrogenic, hypolipidemic, and cytotoxic actions through redox modulation, membrane ...
Parham Joolaei Ahranjani +3 more
wiley +1 more source
Assessing the Effect of Adalimumab in Granuloma Annulare: A Case Series and Literature Review
ABSTRACT Granuloma annulare (GA) is a benign granulomatous skin disorder for which standardized treatment guidelines are lacking due to limited evidence. Adalimumab, a TNF‐α inhibitor, shows promise as a therapeutic option due to its potential to disrupt GA granulomas.
Adriana Caixinha Valorenzos +2 more
wiley +1 more source
Heterogeneous lupus‐specific lesions and treatment outcome, in a single patient, over a period of time [PDF]
The report highlights the importance of strict clinico-histological correlations when skin biopsies are performed in diagnostic doubt in systemic lupus erythematosus.
Agostini, Patrick +5 more
core +2 more sources
Goal. To assess the therapeutic efficacy of the rotation of mid-wavelength ultraviolet therapy (311 nm) and PUVA therapy in patients with moderate to severe forms of psoriasis, and to assess the efficacy of mid-wavelength ultraviolet therapy (311 nm) in ...
M. B. Zhilova, V. V. Chikin
doaj +1 more source
Juvenile Mycosis Fungoides: A Multicenter Retrospective Italian Study
This multicenter retrospective study included 29 juvenile mycosis fungoides (JMF) patients from five Italian centres with confirmed histopathological diagnosis. most often presents with hypopigmented/classic variants and CD8+ phenotype. Early‐onset cases ( < 14 years) show better long‐term outcomes.
Andrea Michelerio +8 more
wiley +1 more source
An unusual case of intertrigo in an adult caused by purely cutaneous Langerhans cell histiocytosis [PDF]
We report a case of persistent intertrigo in an adult, eventually diagnosed as cutaneous Langerhans cell histiocytosis (LCH). It is known that LCH has a predilection for intertriginous areas, however purely cutaneous disease as in our case, is uncommon ...
Baldacchino, Godfrey +3 more
core
Cutaneous Malignant Melanoma Incidences Analyzed Worldwide by Sex, Age, and Skin Type over Personal Ultraviolet-B Dose Shows No Role for Sunburn but Implies One for Vitamin D\u3csub\u3e3\u3c/sub\u3e [PDF]
Because the incidence of cutaneous malignant melanoma (CMM) was reported to increase with increasing terrestrial UVR (290–400 nm) doses in the US back in 1975 and a recent publication showed no association exists with UVR exposure at all, we set out to ...
Godar, Dianne E. +2 more
core +2 more sources
PUVA Induced Bullous Pemphigoid in a Patient with Mycosis Fungoides
Background. Bullous pemphigoid is an autoimmune subepidermal blistering skin disease in which autoantibodies are directed against components of the basement membrane.
Birgül Özkesici +5 more
doaj +1 more source
Klinikai tapasztalataink cutan mastocytosisban. [PDF]
Introduction: Mastocytosis is a clonal mast cell proliferative disease, devided into cutaneous and systemic forms. The characteristic symptoms are caused by neoplastic mast cell infiltrations in different organs and/or the release of mediators.
Csomor, Judit +7 more
core +1 more source
Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee +9 more
wiley +1 more source

