Results 221 to 230 of about 13,926 (255)

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

open access: yesMedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang   +12 more
wiley   +1 more source

Understanding the Distribution of Muscidae Flies and Their Role as Vectors of Bacterial Pathogens in South Africa: A Review Using BOLD Barcoding Data

open access: yesVeterinary Medicine and Science, Volume 12, Issue 3, May 2026.
ABSTRACT The role of Muscidae flies as vectors of bacterial pathogens with veterinary and public health significance necessitates accurate species identification and distribution mapping. This review analysed records from the Barcode of Life Data Systems (BOLD) and the South African National Biodiversity Institute (SANBI) national Diptera checklist ...
Veronica Phetla   +3 more
wiley   +1 more source

Gene‐Informed Modeling of Denitrification Process in Groundwater Through Dynamic Flux Balance Analysis and Deep Learning

open access: yesWater Resources Research, Volume 62, Issue 5, May 2026.
Abstract We introduce two gene‐informed approaches that, for the first time, explicitly incorporate microbial genomic information into groundwater denitrification simulations. First, we couple the dynamic flux balance analysis (DFBA, which resolves genome‐resolved metabolic networks) with the PFLOTRAN reactive transport model (RTM).
Heng Dai   +10 more
wiley   +1 more source

A Hanks‐type bacterial kinase, PknS, directly phosphorylates the alternative sigma factor EcfK to promote resistance to protist predation

open access: yesThe FEBS Journal, Volume 293, Issue 9, Page 2772-2793, May 2026.
The Xanthomonas citri Hanks‐type kinase PknS autophosphorylates and directly phosphorylates the alternative sigma factor EcfK at five residues. Besides the conserved residue T51 in the σ2 domain, phosphorylation of a residue in the linker between σ2 and σ4 is critical for EcfK activation by promoting its interaction with a positively charged pocket in ...
Lídia dos Passos Lima   +12 more
wiley   +1 more source

Multiple Periapical Lesions Influence the Expression of TLR4/NF‐κB Pathway Components and the Development of Hepatic Injuries in Healthy and Chronic Alcohol‐Consuming Rats

open access: yesInternational Endodontic Journal, Volume 59, Issue 5, Page 863-872, May 2026.
ABSTRACT Aim To evaluate the impact of multiple apical periodontitis (AP) on the expression of TLR4/NF‐κB pathway components, proinflammatory cytokine levels, and development of hepatic injuries in rats with and without chronic alcohol consumption. Methodology Thirty‐two rats were assigned to four groups (n = 8): Control, AP, Alcohol, and Alcohol+AP ...
Karem Paula Pinto   +6 more
wiley   +1 more source

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