Results 11 to 20 of about 1,150 (103)

The slow de-implementation of non-evidence-based treatments in low back pain hospital care-Trends in treatments using Dutch hospital register data from 1991 to 2018. [PDF]

Eur J Pain, 2023
Abstract Background Low back pain (LBP) is the leading cause of disability worldwide and has an excessive societal burden. Accumulating evidence has shown that some medical approaches such as imaging in absence of clear indications, medication and some invasive treatments may contribute to the problem rather than alleviating it. Objectives To determine
Coenen P, de Wind A, van de Ven P, de Maaker-Berkhof M, Koes B, Buchbinder R, Hartvigsen J, Anema JHR.   +7 more
europepmc   +2 more sources

Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19. [PDF]

J Pathol, 2022
Abstract COVID‐19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID‐19 patients, we found extensive accumulation of the tryptophan degradation products 3‐hydroxy‐anthranilic acid and quinolinic acid in the lungs, heart, and brain.
Guo L, Schurink B, Roos E, Nossent EJ, Duitman JW, Vlaar AP, van der Valk P, Vaz FM, Yeh SR, Geeraerts Z, Dijkhuis A, van Vught L, Bugiani M, Lutter R, also on behalf of the Amsterdam UMC COVID-19 Biobank Study Group.   +14 more
europepmc   +2 more sources

In vitro and in vivo investigation of the biological action of xylooligosaccharides derived from industrial waste. [PDF]

Food Sci Nutr
The study revealed that xylooligosaccharides (XOS) derived from Mongolian food manufacturing by‐products such as wheat bran and brewer's grain promoted good gut bacteria and protect intestinal mucus. It demonstrated that XOS concentration promoted bacterial growth, particularly in Bifidobacterium spp. and Akkermansia. muciniphila.
Chinbat O, Erdenetsog P, Tuvshintur B, Gantumur A, Burenjargal M, Chimeddorj B, Janlav M.   +6 more
europepmc   +2 more sources

Inkjet‐Printed Microlenses Integrated onto Organic Photodiodes for Highly Accurate Proximity Sensing

Advanced Sensor Research, Volume 2, Issue 8, August 2023., 2023
Printed microlenses are integrated onto organic photodiodes to enable the focus induced photoresponse effect for optical proximity measurements. By comparing the photocurrent ratio of a device with and without microlenses, absolute proximity measurements in the range of 100 μm–4 mm and an accuracy of down to ±50 μm within three standard deviations (3σ)
Mervin Seiberlich, Qiaoshuang Zhang, Ali Veysel Tunc, Kai Xia, Luis Arturo Ruiz‐Preciado, Stefan Schlisske, Konstantinos Falis, Noah Strobel, Uli Lemmer, Gerardo Hernandez‐Sosa   +9 more
wiley   +1 more source

ONC201 induces the unfolded protein response (UPR) in high‐ and low‐grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity

Cancer Medicine, Volume 10, Issue 10, Page 3373-3387, May 2021., 2021
ONC201 can effectively overcome chemoresistance in both high‐grade and low‐grade ovarian cancer cells by blocking pro‐survival pathways and inducing the apoptotic arm of the UPR. A weekly oral dose of ONC201 lowers the tumor burden in mice. This is a promising therapeutic agent in OVCA treatment and might consider for clinical translation.
Marufa Rumman, Steven Buck, Lisa Polin, Sijana Dzinic, Julie Boerner, Ira S. Winer   +5 more
wiley   +1 more source

A Covalent Triazine Framework for Photocatalytic Anti‐Markovnikov Hydrofunctionalizations

Angewandte Chemie, Volume 136, Issue 52, December 20, 2024.
Anti‐Markovnikov hydro‐functionalization of alkenes is essential for synthesizing natural products, medicinally relevant compounds, and other important molecules. In this context, photocatalysis has emerged as a crucial tool for these reactions. However, existing methods rely on either expensive, or scarce metal photocatalysts, rendering this strategy ...
Rakesh Maiti, Jeet Chakraborty, Prakash Kumar Sahoo, Ipsita Nath, Xingchao Dai, Jabor Rabeah, Nathalie De Geyter, Rino Morent, Pascal Van Der Voort, Shoubhik Das   +9 more
wiley   +2 more sources

Efecto del momento y tipo de poda sobre el rendimiento y calidad del fruto en arándano altos del sur (Vaccinium corymbosum) var. O´Neal en la provincia de Buenos Aires [PDF]

RIA: Revista Investigaciones Agropecuarias, 2011
ResumenLa poda es una práctica que beneficia no sólo la calidad y cantidad de los frutos, sino también favorece la preservación de la planta como unidad productiva. Tiene distintos objetivos dependiendo de su intensidad y del momento de realización.
PESCIE, M, BORDA, M, FEDYSZAK, P, LÓPEZ, C   +3 more
doaj  

Selective glucocorticoid receptor properties of GSK866 analogs with cysteine reactive warheads [PDF]

, 2017
Synthetic glucocorticoids (GC) are the mainstay therapy for treatment of acute and chronic inflammatory disorders. Due to the high adverse effects associated with long-term use, GC pharmacology has focused since the nineties on more selective GC ligand ...
Atucha, Avenant, Baiula, Barnes, Bauer, Baumer, Beck, Berk, Biggadike, Bledsoe, Bonvini, Carson, Cheatham, Chen, Corne, De Bosscher, De Bosscher, De Bosscher, De Vos, Desmet, Desmet, Engel, Garuti, Helsens, Lieber, Liu, Madauss, Mcmaster, Meijsing, Newton, Newton, Perkins, Proksch, Ratman, Rehman, Reichardt, Rhen, Roskoski, Ryabtsova, Schacke, Schacke, Schacke, Schacke, Schindelin, Schuttelkopf, Shafiee, Simons, Simons, Simons, Singh, Sundahl, Touw, Trott, Vanden Berghe, Vanden Berghe, Vandevyver, Vane, Vanhaesebroeck, Verschuuren, Vettorazzi, Wang, Werkstrom   +61 more
core   +2 more sources

Quantized time correlation function approach to non-adiabatic decay rates in condensed phase: Application to solvated electrons in water and methanol [PDF]

, 2006
A new, alternative form of the golden rule formula defining the non-adiabatic transition rate between two quantum states in condensed phase is presented.
Bader J. S., Berne B. J., Daniel Borgis, Kubo R., László Turi, May V., Mukamel S., Oxtoby D. W., Peter J. Rossky   +8 more
core   +3 more sources

Involvement of NF‐κB/IL‐6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice

International Journal of Inflammation, Volume 2014, Issue 1, 2014., 2014
Nuclear factor‐kappaB (NF‐κB)/interleukin (IL‐6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF‐κB/IL‐6 pathway during the procession of experimental CAC mouse model.
Hang Yang, Haili Qi, Jingli Ren, Jing Cui, Zhenfeng Li, Helge L. Waldum, Guanglin Cui, Jonathan Steven Alexander   +7 more
wiley   +1 more source