Results 11 to 20 of about 1,127 (96)

The slow de-implementation of non-evidence-based treatments in low back pain hospital care-Trends in treatments using Dutch hospital register data from 1991 to 2018. [PDF]

Eur J Pain, 2023
Abstract Background Low back pain (LBP) is the leading cause of disability worldwide and has an excessive societal burden. Accumulating evidence has shown that some medical approaches such as imaging in absence of clear indications, medication and some invasive treatments may contribute to the problem rather than alleviating it. Objectives To determine
Coenen P, de Wind A, van de Ven P, de Maaker-Berkhof M, Koes B, Buchbinder R, Hartvigsen J, Anema JHR.   +7 more
europepmc   +2 more sources

Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19. [PDF]

J Pathol, 2022
Abstract COVID‐19 is a pandemic with high morbidity and mortality. In an autopsy cohort of COVID‐19 patients, we found extensive accumulation of the tryptophan degradation products 3‐hydroxy‐anthranilic acid and quinolinic acid in the lungs, heart, and brain.
Guo L, Schurink B, Roos E, Nossent EJ, Duitman JW, Vlaar AP, van der Valk P, Vaz FM, Yeh SR, Geeraerts Z, Dijkhuis A, van Vught L, Bugiani M, Lutter R, also on behalf of the Amsterdam UMC COVID-19 Biobank Study Group.   +14 more
europepmc   +2 more sources

A Novel Fibroblast Activation Protein-Based Algorithm to Assess Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

J Gastroenterol Hepatol
To improve triage for liver fibrosis in MASLD primary care and where elastography is unavailable, a novel algorithm, FAP Index, that requires one fibrogenesis‐relevant, rapid enzyme assay, was devised and validated. FAP Index increased advanced fibrosis risk stratification accuracy by greatly reducing the frequency of indeterminate results compared to ...
Wang ZV, Boumelhem BB, Pennell T, Bachovchin WW, Lai JH, Poplawski SE, Chandraratna H, Van Der Veken P, Brewer K, Leeming DJ, Ooi G, George J, Eslam M, Adams LA, Zhang HE, McCaughan GW, Majumdar A, Gorrell MD.   +17 more
europepmc   +2 more sources

Effects of Interfacial Adhesion on Lithium Plating Location in Solid-State Batteries with Carbon Interlayers. [PDF]

Adv Mater
Carbon interlayers can promote the stable cycling of anode‐free solid‐state batteries, but their underlying mechanisms have remained elusive. In this study, a direct correlation is observed between the interfacial adhesion of the carbon interlayer and the location of lithium plating.
Liao DW, Zeng D, Mulla M, Madanchi A, Kawakami H, Aihara Y, Aotani K, Thouless MD, Dasgupta NP.   +8 more
europepmc   +2 more sources

In vitro and in vivo investigation of the biological action of xylooligosaccharides derived from industrial waste. [PDF]

Food Sci Nutr
The study revealed that xylooligosaccharides (XOS) derived from Mongolian food manufacturing by‐products such as wheat bran and brewer's grain promoted good gut bacteria and protect intestinal mucus. It demonstrated that XOS concentration promoted bacterial growth, particularly in Bifidobacterium spp. and Akkermansia. muciniphila.
Chinbat O, Erdenetsog P, Tuvshintur B, Gantumur A, Burenjargal M, Chimeddorj B, Janlav M.   +6 more
europepmc   +2 more sources

Inkjet‐Printed Microlenses Integrated onto Organic Photodiodes for Highly Accurate Proximity Sensing

Advanced Sensor Research, Volume 2, Issue 8, August 2023., 2023
Printed microlenses are integrated onto organic photodiodes to enable the focus induced photoresponse effect for optical proximity measurements. By comparing the photocurrent ratio of a device with and without microlenses, absolute proximity measurements in the range of 100 μm–4 mm and an accuracy of down to ±50 μm within three standard deviations (3σ)
Mervin Seiberlich, Qiaoshuang Zhang, Ali Veysel Tunc, Kai Xia, Luis Arturo Ruiz‐Preciado, Stefan Schlisske, Konstantinos Falis, Noah Strobel, Uli Lemmer, Gerardo Hernandez‐Sosa   +9 more
wiley   +1 more source

ONC201 induces the unfolded protein response (UPR) in high‐ and low‐grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity

Cancer Medicine, Volume 10, Issue 10, Page 3373-3387, May 2021., 2021
ONC201 can effectively overcome chemoresistance in both high‐grade and low‐grade ovarian cancer cells by blocking pro‐survival pathways and inducing the apoptotic arm of the UPR. A weekly oral dose of ONC201 lowers the tumor burden in mice. This is a promising therapeutic agent in OVCA treatment and might consider for clinical translation.
Marufa Rumman, Steven Buck, Lisa Polin, Sijana Dzinic, Julie Boerner, Ira S. Winer   +5 more
wiley   +1 more source

A Covalent Triazine Framework for Photocatalytic Anti‐Markovnikov Hydrofunctionalizations

Angewandte Chemie, Volume 136, Issue 52, December 20, 2024.
Anti‐Markovnikov hydro‐functionalization of alkenes is essential for synthesizing natural products, medicinally relevant compounds, and other important molecules. In this context, photocatalysis has emerged as a crucial tool for these reactions. However, existing methods rely on either expensive, or scarce metal photocatalysts, rendering this strategy ...
Rakesh Maiti, Jeet Chakraborty, Prakash Kumar Sahoo, Ipsita Nath, Xingchao Dai, Jabor Rabeah, Nathalie De Geyter, Rino Morent, Pascal Van Der Voort, Shoubhik Das   +9 more
wiley   +2 more sources

Involvement of NF‐κB/IL‐6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice

International Journal of Inflammation, Volume 2014, Issue 1, 2014., 2014
Nuclear factor‐kappaB (NF‐κB)/interleukin (IL‐6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF‐κB/IL‐6 pathway during the procession of experimental CAC mouse model.
Hang Yang, Haili Qi, Jingli Ren, Jing Cui, Zhenfeng Li, Helge L. Waldum, Guanglin Cui, Jonathan Steven Alexander   +7 more
wiley   +1 more source

The Photon‐Baryon Governed Universe

Physics Research International, Volume 2012, Issue 1, 2012., 2012
In a previous paper we postulated that the repulsive force responsible for the universal expansion is associated with the excitation of the empty space (quantum vacuum) and the excitation energy is represented by the energy of the cosmic microwave background (CMB). In this paper, we show that the concept of the repulsive space expanding photon field (i)
Laszlo A. Marosi, C. P. Singh
wiley   +1 more source