Results 11 to 20 of about 17,859 (165)

Clustering Properties of Neuronal Ryanodine Receptor 2 and Remodeling in the APP/PS1 Mouse Model of Alzheimer's Disease. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim The ryanodine receptor (RyR2) is an intracellular Ca2+ release channel which mediates numerous cellular functions across different tissues. Dysregulation of RyR2 channel activity leads to pathological Ca2+ release, which often underlies disrupted cellular signaling in disease states.
Munro ML, Silva RV, Ohline SM, Khaing EP, Chan JA, Ibrahim MF, Tausi TF, Abraham WC, Jones PP.   +8 more
europepmc   +2 more sources

Reduced Non-Specific Binding of Super-Resolution DNA-PAINT Markers by Shielded DNA-PAINT Labeling Protocols. [PDF]

Small
Conventional immunohistochemistry labeling with oligonucleotide conjugated secondary antibodies can lead to significant non‐specific uptake across biological cells and is especially prominent within the nucleus. By adding a pre‐incubation step with fully or partially complementary strands and increasing the ionic strength of the buffer this non ...
Lučinskaitė E, Bokhobza AFE, Stannard A, Meletiou A, Estell C, West S, Michele LD, Soeller C, Clowsley AH.   +8 more
europepmc   +3 more sources

Substrate-Affinitive P-Type Azapolycyclic Photosensitizer for Chemoselective Nitrilization Under Mild Conditions. [PDF]

Adv Sci (Weinh)
We developed a series of quinoxalinoquinoxaline (QQ) photosensitizers featuring high and tunable excited‐state reduction potentials (E(PC•+/PC*) = –1.76 to –2.05 V vs. SCE). Their hydrogen‐bonding interaction with carbonyl substrates enables selective single‐electron transfer events for selective nitrilization of 1° amides, offering a tunable ...
Bae S, Kim D, Kim J.
europepmc   +2 more sources

Solution Structure and Relaxivity of Ln‐DOTXAZA Derivatives

European Journal of Inorganic Chemistry, Volume 2022, Issue 32, November 17, 2022., 2022
Gd‐Based contrast agents (GBCAs) are essential reagents in clinical diagnosis via MRI. We report four members of the DOTXAZA series, which are valuable scaffolds for the assembly of new GBCAs with improved relaxivity and tailored pharmacokinetic or targeting properties by Cu‐catalyzed alkyne‐azide cycloaddition (CuAAC).
Malte Holzapfel, Torben Baldau, Svenja Kerpa, Gianmarco Guadalupi, Bing Qi, Yang Liu, Wolfgang J. Parak, Wolfgang Maison   +7 more
wiley   +1 more source

Research trends analysis of chronic hepatitis C versus nonalcoholic fatty liver disease: A literature review text‐mining analysis of publications

Health Science Reports, Volume 5, Issue 6, November 2022., 2022
Abstract Background Hepatits C virus (HCV) rates have lowered due to direct‐acting antiviral treatment. Nonalcoholic steatohepatitis (NASH)/nonalcoholic fatty liver disease (NAFLD) is rising with no available therapy. We employed text‐mining to analyze trends in HCV and NAFLD research from the past two decades.
Eyal Klang, Shelly Soffer, Lee Alper, Orit Shimon, Yiftach Barash, Yana Davidov, Mariya Likhter, Oranit Cohen‐Ezra, Gil Ben Yakov, Ziv Ben‐Ari   +9 more
wiley   +1 more source

Sustainable university entrepreneurship: Revisiting firm growth patterns

Business Strategy and the Environment, Volume 31, Issue 4, Page 1334-1346, May 2022., 2022
Abstract Previous research on the firm growth of the university spin‐offs (USOs) and its drivers yields inconclusive results. Recently, the literature on the high‐growth firms (HGFs) has relied on regression quantile methods to study how the effects of growth determinants may differ along the firm growth distribution. This study builds a bridge between
Sara Fernández‐López, David Rodeiro‐Pazos, María Jesús Rodríguez‐Gulías, Manuel Anxo Nogueira‐Moreiras   +3 more
wiley   +1 more source

Trends in inflammatory bowel disease treatment in the past two decades‐a high‐level text mining analysis of PubMed publications

United European Gastroenterology Journal, Volume 9, Issue 9, Page 1019-1026, November 2021., 2021
Abstract Aim Many therapeutic options for inflammatory bowel disease (IBD) emerged during the last 2 decades, along with the rise in disease prevalence and incidence. We aimed at assessing the published literature on different treatment options in that period.
Eyal Klang, Yiftach Barash, Shelly Soffer, Eyal Shachar, Adi Lahat   +4 more
wiley   +1 more source

Efectos del aval de las SGRs en la financiación de las PYME y los requerimientos de capital de Basilea II [PDF]

, 2006
El objetivo del presente trabajo es analizar cómo influye el aval que las Sociedades de Garantía Recíproca (SGR) conceden a las Pequeñas y Medianas Empresas (PYME) en los fondos propios exigidos a las entidades financieras en el nuevo Acuerdo de Capital,
Cardone Riportella, Clara, Trujillo Ponce, Antonio   +1 more
core   +1 more source

La Empresa de Comunicación como PYME [PDF]

, 2010
Definición y descripción de la PYME de ...
González-Díaz, Cristina
core   +1 more source

Caracterización del sujeto Pyme [PDF]

, 2022
El objetivo del trabajo es determinar la caracterización de un Constructo denominado Sujeto Pyme, a parir de un análisis multivariante. Es decir, contemplar la definición del Sujeto Pyme considerando diferentes constructos que la componen con sus ...
Muñoz, Julio César
core