Results 101 to 110 of about 4,864,845 (302)

Atypical hippocampal excitatory neurons express and govern object memory

Nature Communications
Classically, pyramidal cells of the hippocampus are viewed as flexibly representing spatial and non-spatial information. Recent work has illustrated distinct types of hippocampal excitatory neurons, suggesting that hippocampal representations and ...
Adrienne I. Kinman, Derek N. Merryweather, Sarah R. Erwin, Regan E. Campbell, Kaitlin E. Sullivan, Larissa Kraus, Margarita Kapustina, Brianna N. Bristow, Mingjia Y. Zhang, Madeline W. Elder, Sydney C. Wood, Ali Tarik, Esther Kim, Joshua Tindall, William Daniels, Mehwish Anwer, Caiying Guo, Mark S. Cembrowski   +17 more
doaj   +1 more source

Autapses enhance bursting and coincidence detection in neocortical pyramidal cells

Nature Communications, 2018
While autapses are synapses made by a neuron onto itself, its functional significance in pyramidal cells are not clear. Here, the authors show that in the mammalian neocortex, autapses of pyramidal cells can enhance burst firing and coincidence detection
Luping Yin, Rui Zheng, Wei Ke, Quansheng He, Yi Zhang, Junlong Li, Bo Wang, Zhen Mi, Yue-sheng Long, Malte J. Rasch, Tianfu Li, Guoming Luan, Yousheng Shu   +12 more
doaj   +1 more source

Objective Morphological Classification of Neocortical Pyramidal Cells

Cerebral Cortex, 2019
A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, which is based on expert analyses of neuronal morphologies.
Kanari, Lida, Ramaswamy, Srikanth, Shi, Ying, Morand, Sebastien, Meystre, Julie, Perin, Rodrigo, Abdellah, Marwan, Wang, Yun, Hess, Kathryn, Markram, Henry   +9 more
openaire   +4 more sources

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Postnatal development of intrinsic and synaptic properties transforms signaling in the Layer 5 excitatory neural network of the visual cortex [PDF]

, 2011
Information flow in neocortical circuits is regulated by two key parameters: intrinsic neuronal properties and the short-term activity-dependent plasticity of synaptic transmission.
Etherington, Sarah J., S. J. Etherington, S. R. Williams, Etherington, S.J., Williams, S.R., Williams, Stephen R.   +5 more
core   +1 more source

Altered dendritic morphology of MEC II pyramidal and stellate cells in Rett syndrome mice

Frontiers in Neuroanatomy
IntroductionMutations in the methyl-CpG-binding protein-2 gene (MECP2), which cause Rett syndrome (RTT), disrupt neuronal activity; however, the impact of the MECP2 loss-of-function on the cytoarchitecture of medial entorhinal cortex layer II (MECII ...
Manigandan Krishnan, Ayishal B. Mydeen, Mohammed M. Nakhal, Marwa F. Ibrahim, Richard L. Jayaraj, Milos R. Ljubisavljevic, Mohammad I. K. Hamad, Fatima Y. Ismail, Fatima Y. Ismail   +8 more
doaj   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source

Large and fast human pyramidal neurons associate with intelligence

eLife, 2018
It is generally assumed that human intelligence relies on efficient processing by neurons in our brain. Although grey matter thickness and activity of temporal and frontal cortical areas correlate with IQ scores, no direct evidence exists that links ...
Natalia A Goriounova, Djai B Heyer, René Wilbers, Matthijs B Verhoog, Michele Giugliano, Christophe Verbist, Joshua Obermayer, Amber Kerkhofs, Harriët Smeding, Maaike Verberne, Sander Idema, Johannes C Baayen, Anton W Pieneman, Christiaan PJ de Kock, Martin Klein, Huibert D Mansvelder   +15 more
doaj   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Basic subthreshold and suprathreshold electrophysiological properties of RS versus RB pyramidal cells.

, 2016
Basic subthreshold and suprathreshold electrophysiological properties of RS versus RB pyramidal cells.
Alexandre J. C. Loucif (3195849), Dirk Schubert (2440621), Jochen F. Staiger (2566063), Martin Möck (3195852)   +3 more
core   +1 more source