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Cholinergic excitation of mammalian hippocampal pyramidal cells

Brain Research, 1982
Responses of CA1 pyramidal neurons to ACh were recorded with intracellular microelectrodes utilizing the in vitro guinea pig hippocampal slice preparation. ACh was delivered by drop or iontophoretic application to stratum oriens or stratum radiatum. Threshold dose for drop application was 1 mM.
L S, Benardo, D A, Prince
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Mysterious hexagonal pyramids on the surface of Pyrobaculum cells

Biochimie, 2015
In attempts to induce putative temperate viruses, we UV-irradiated cells of the hyperthermophilic archaeon Pyrobaculum oguniense. Virus replication could not be detected; however, we observed the development of pyramidal structures with 6-fold symmetry on the cell surface. The hexagonal basis of the pyramids was continuous with the cellular cytoplasmic
Rensen, Elena   +2 more
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Cholinergic pharmacology of mammalian hippocampal pyramidal cells

Neuroscience, 1982
Responses of CAl pyramidal cells to cholinergic compounds were recorded with intracellular microelectrodes in guinea-pig hippocampal slices. Perfusion of slices with medium containing the muscarinic antagonists atropine or scopolamine (10(-7)-10(-6)M) blocked all actions of acetylcholine.
L S, Benardo, D A, Prince
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Basilar dendrite bundles of giant pyramidal cells

Experimental Neurology, 1974
Abstract Giant pyramidal cells of Betz from primary motor cortex and large solitary cells of Meynert from the visual cortex appear to share certain characteristics including extraordinary length of their basilar dendrites and the organization of these dendrite shafts into bundles.
M E, Scheibel   +3 more
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Mechanisms of Electrical Coupling Between Pyramidal Cells

Journal of Neurophysiology, 1997
Vigmond, Edward J., Jose L. Perez Velazquez, Taufik A. Valiante, Berj L. Bardakjian, and Peter L. Carlen. Mechanisms of electrical coupling between pyramidal cells. J. Neurophysiol. 78: 3107–3116, 1997. Direct electrical coupling between neurons can be the result of both electrotonic current transfer through gap junctions and extracellular fields ...
E J, Vigmond   +4 more
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Reduced compartmental models of neocortical pyramidal cells

Journal of Neuroscience Methods, 1993
Model neurons composed of hundreds of compartments are currently used for studying phenomena at the level of the single cell. Large network simulations require a simplified model of a single neuron that retains the electrotonic and synaptic integrative properties of the real cell.
P C, Bush, T J, Sejnowski
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Plasmonic Tipless Pyramid Arrays for Cell Poration

Nano Letters, 2015
Improving the efficiency, cell survival, and throughput of methods to modify and control the genetic expression of cells is of great benefit to biology and medicine. We investigate, both computationally and experimentally, a nanostructured substrate made of tipless pyramids for plasmonic-induced transfection.
Courvoisier, Sébastien   +7 more
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Pyramid power: Principal cells of the hippocampus unite!

Brain Cell Biology, 2007
Electrical transmission in the mammalian brain is now well established. A new study by Thomson and colleagues elegantly demonstrates coupling between CA1 hippocampal pyramidal cells, which is far more common than previously supposed. Although the history of coupling is extensive, doubt, predjudice, and technical issues long kept it from wide acceptance.
Michael V L, Bennett, Alberto, Pereda
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Some Mechanisms Controlling Hippocampal Pyramidal Cells

1983
Publisher Summary Early studies of the neuromuscular junction and on motoneurons formed certain classical concepts about mechanisms controlling excitable cells. Excitation was shown to be caused by a relatively non-specific permeability increase of the synaptic membrane (“short-circuit”), while inhibition was shown to be because of a specific ...
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Pyramidal Nerve Cell Loss in Alzheimer's Disease

Neurodegeneration, 1996
Loss of the large pyramidal cells of the association neocortex and hippocampus, along with plaques and tangles, is fundamental to the neuropathology of Alzheimer's disease. The extent of Alzheimer-specific cell loss, relative to controls, is age-dependent with maximal losses in younger subjects though, because of the (additive) effects of 'normal ...
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