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SYNTHESIS OF NEW PYRIDAZIN- 6-ONES, PYRIDAZIN-6-IMINES, 4-PYRIDAZINALS, AND PYRIDINES
Synthetic Communications, 2002ABSTRACT 3-Dimethyl-1-[3-methyl-(4H)-5-phenylimidazol[2,1-b]thiazol-2-yl]prop-2-enone 4 couples smoothly with benzenediazonium chloride to yield propanal 5 which is a key intermediate for the synthesis of pyridazinones 9–13, 16 and pyridazine-6-imine 8, 19.
Samia M. Sayed +3 more
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Pyridazines. XXIII. A novel pyridazine into pyrazole ring transformation
Journal of Heterocyclic Chemistry, 1984AbstractTreatment of phenyl(4‐pyridazinyl)methanols 1a and 1b with p‐toluenesulfonic acid at elevated temperatures causes transformation into the C‐4 substituted pyrazole derivatives 8a and 8b. Limitations of this novel rearrangement reaction as well as mechanistic considerations are discussed.
Gottfried Heinisch, Richard Waglechner
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[Biotransformation of pyridazines. 1. Pyridazine and 3-methylpyridazine].
Die Pharmazie, 1990Pyridazin (1) and 3-methylpyridazine (6) undergo oxidative biotransformation in an unexpected high degree. Beside the unchanged compounds, after administration of 1 two isomeric monohydroxylated products (2, 3), 4,5-dihydrodihydroxypyridazine (4) and 4,5-dihydroxypyridazine (5) and after administration of 6 one ringhydroxylated 6-derivative (7), 3 ...
H H, Borchert +4 more
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Pyridazines. LXXXIV. Studies on borohydride reduction of pyridazine compounds
Journal of Heterocyclic Chemistry, 1976AbstractImidazo[1,2‐b]pyridazine, s‐triazolo[4,3‐b]pyridazine and tetrazolo[1,5‐b]pyridazine and some derivatives thereof were reduced with sodium borohydride to give the corresponding 5,6,7,8‐tetrahydro derivatives. A mechanism for these reductions is proposed and reduction at the C7‐C8 bond occurs before the reduction of the C6N5 bond.
P. K. Kadaba, B. Stanovnik, M. Tišler
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[1,2,4]Triazolo[4,3-b]pyridazine as a building block towards low-sensitivity high-energy materials
Chemical Engineering Journal, 2021Sitong Chen +2 more
exaly
Pyridazines. XXXVII. Pyrimido[1,2-b]pyridazines
The Journal of Organic Chemistry, 1971Miha Tisler +2 more
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Imidazo[1,2-b]pyridazine as privileged scaffold in medicinal chemistry: An extensive review
European Journal of Medicinal Chemistry, 2021Gonzalo Vera +1 more
exaly