Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
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Expanding the Trifluoroborate Toolbox: Pyridinium Scaffolds for PET Tracer Development. [PDF]
Wong AAWL, Perrin DM.
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Efficient and versatile supramolecular functionalization of polysilicon microchips with cationic amphiphile salts for incorporation of therapeutics. [PDF]
Alea-Reyes ME +4 more
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Orchestrating Anion–π+ Interactions to Accelerate Metal‐Free Room‐Temperature Phosphorescence
Tuning anion–π+ interactions in pyridinium iodide contact ion pairs enables ultrafast metal‐free room‐temperature phosphorescence (540–605 nm) with radiative rates up to 5.2×105 s−1. Strong iodide→π+ charge‐transfer coupling, enhanced spin–orbit interactions, and dynamic ion‐pair organization accelerate intersystem crossing and emission, establishing ...
Eetu Hakkarainen +12 more
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Positional isomerization of pyridine through nitrogen transposition. [PDF]
Choi W, Ju H, Park J, Hong S.
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The Sulfonation of Acetone: Characterization of Acetonedisulfonic Acid and Its Salts. [PDF]
Langwald J +3 more
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Structural and Spectroscopic Evidence of Hydrogen Bonded Anionic Wires in Protic Ionic Liquids
Anionic wires of deprotonated carboxylic acids challenge the general wisdom that like charges repel. The hydrogen bond motif observed in the X‐ray structure is even preserved in the liquid state of the material as shown by δ1H NMR spectroscopy. The experimental and theoretical findings provide deep insight into the nature of hydrogen bonding.
Maham Azhar +5 more
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Exploring Polyene Construction Tactics for the Total Synthesis of Ocular Pyridinium Bisretinoids of Lipofuscin A2E and pdA2E. [PDF]
Vidal B +3 more
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Encapsulation of Porphyrins in Polymer Microgels and Microbeads for Heterogeneous Photooxidation
Amino‐ or ammonium‐functionalized tetraphenylporphyrins were synthesized and encapsulated within polymers to form microgels and microbeads that act as heterogeneous photocatalysts. Photooxidation in aqueous media quantitatively converts sulfides and aldehydes into sulfoxides and carboxylic acids via the singlet‐oxygen pathway, demonstrating an ...
Imogen Smith +3 more
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