Results 91 to 100 of about 888,200 (233)

The PII-NAGK-PipX-NtcA Regulatory Axis of Cyanobacteria: A Tale of Changing Partners, Allosteric Effectors and Non-covalent Interactions

Frontiers in Molecular Biosciences, 2018
PII, a homotrimeric very ancient and highly widespread (bacteria, archaea, plants) key sensor-transducer protein, conveys signals of abundance or poorness of carbon, energy and usable nitrogen, converting these signals into changes in the activities of ...
Alicia Forcada-Nadal, Alicia Forcada-Nadal, José Luis Llácer, José Luis Llácer, Asunción Contreras, Clara Marco-Marín, Clara Marco-Marín, Vicente Rubio, Vicente Rubio   +8 more
doaj   +1 more source

Deletion mutagenesis of large areas in Plasmodium falciparum genes: a comparative study

Malaria Journal, 2007
Background The increasing emergence of Plasmodium falciparum parasites resistant to most of the cost-effective drugs has necessitated the identification of novel leads and drug targets.
Birkholtz Lyn-Marie, Louw Abraham I, Williams Marni   +2 more
doaj   +1 more source

Human Pyridoxal Kinase [PDF]

Journal of Biological Chemistry, 1997
Michael C. Hanna, Anthony J. Turner, Ewen F. Kirkness   +2 more
openaire   +1 more source

FK960 binding proteins, quinone oxidoreductase2 and pyridoxal kinase were identified by LC-MS/MS for drug discovery of Alzheimer's treatment

, 2018
We established new LC-MS/MS methodology of the target proteome of unknown proteins in cytoplasm of hippocampus for Drug Discovery of Alzheimer's Treatment.
Z. Tozuka, Akihiro Kunisawa, F. Shirai, Y. Ishii   +3 more
semanticscholar   +1 more source

Identification of testis development-related genes by combining Iso-Seq and RNA-Seq in Zeugodacus tau

Frontiers in Cell and Developmental Biology
Introduction:Zeugodacus tau (Walker) is an invasive pest. An effective method to control this pest is the sterile insect technique (SIT). To better apply this technique, it is necessary to understand testis development progression.Methods: Differentially
Peipei Liu, Peipei Liu, Peipei Liu, Peipei Liu, Peipei Liu, Ziniu Li, Ziniu Li, Ziniu Li, Ziniu Li, Ziniu Li, Qiuyuan Zhang, Qiuyuan Zhang, Qiuyuan Zhang, Qiuyuan Zhang, Qiuyuan Zhang, Jiao Qiao, Jiao Qiao, Jiao Qiao, Jiao Qiao, Jiao Qiao, Chenjun Zheng, Chenjun Zheng, Chenjun Zheng, Chenjun Zheng, Chenjun Zheng, Wenping Zheng, Wenping Zheng, Wenping Zheng, Wenping Zheng, Wenping Zheng, Hongyu Zhang, Hongyu Zhang, Hongyu Zhang, Hongyu Zhang, Hongyu Zhang   +34 more
doaj   +1 more source

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

Advanced Science
Risk stratification using multi‐omics data deepens understanding of immunometabolism in successfully treated people with HIV (PWH) is inadequately explained.
Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro deMagalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi   +32 more
doaj   +1 more source

Intratumoral CXCL13+ CD160+ CD8+ T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer

Journal for ImmunoTherapy of Cancer
Background Stage IV gastric cancer is a highly heterogeneous and lethal tumor with few therapeutic strategies. The combination of programmed cell death protein 1 inhibitors and chemotherapy is currently the standard frontline treatment regimen for ...
Yuan Liang, Yuan Li, Li Yang, Zekuan Xu, Jian Xiao, Xinyu Zhao, Jiawei Wang, Ao Xue, Shuqing Cao, Pengyu Li, Jiacheng Dong   +10 more
doaj   +1 more source

The PdxR-PdxKU locus involved in vitamin B6 salvage is important for group A streptococcal resistance to neutrophil killing and survival in human blood

Microbiology Spectrum
Streptococcus pyogenes (Group A Streptococcus, GAS) is a Gram-positive bacterium that inflicts both superficial and life-threatening diseases on its human host.
Sarah E. Davis, Meaghan T. Hart, Rezia Era D. Braza, Aolani A. Perry, Luis A. Vega, Yoann S. Le Breton, Kevin S. McIver   +6 more
doaj   +1 more source

The role of micronutrients on the treatment of diabetes

Human Nutrition & Metabolism
In the last two decades, there has been a significant increase in the number of individuals worldwide who are affected by diabetes. This review article aims to explore the correlation between specific vitamins and diabetes.
Samer Younes
doaj   +1 more source

The role of pyridoxine as a countermeasure for in-flight loss of lean body mass [PDF]

Ground based and in flight research has shown that humans, under conditions of microgravity, sustain a loss of lean body tissue (protein) and changes in several biological processes including, reductions in red blood cell mass, and neurotransmitters. The
Gilbert, Joyce A.
core   +1 more source