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Journal of Biomolecular Structure and Dynamics, 2023
Pyridoxal kinase (PDXK) is a vitamin B6-dependent transferase enzyme encoded by the PDXK gene, crucial for leukemic cell proliferation. Disruption of its activity causes altered metabolism and reduced levels of nucleotides and polyamines.
Pallabi Banerjee +5 more
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Pyridoxal kinase (PDXK) is a vitamin B6-dependent transferase enzyme encoded by the PDXK gene, crucial for leukemic cell proliferation. Disruption of its activity causes altered metabolism and reduced levels of nucleotides and polyamines.
Pallabi Banerjee +5 more
semanticscholar +1 more source
Thiamine‐dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo
Journal of Neurochemistry, 2022Vitamins B1 (thiamine) and B6 (pyridox (al/ine/amine)) are crucial for central nervous system (CNS) function and neurogenesis due to the coenzyme action of their phosphorylated derivatives in the brain metabolism of glucose and neurotransmitters.
V. Bunik +8 more
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Current protein and peptide science, 2022
Human parasites cause several diseased conditions with high morbidity and mortality in a large section of population residing in various geographical areas.
M. Saini, S. Are, I. Qureshi
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Human parasites cause several diseased conditions with high morbidity and mortality in a large section of population residing in various geographical areas.
M. Saini, S. Are, I. Qureshi
semanticscholar +1 more source
Annals of the New York Academy of Sciences, 1990
Chymotryptic digestion of sheep brain pyridoxal kinase, a dimer of identical subunits each of 40 kDa, yields two fragments of 24 and 16 kDa with concomitant loss of catalytic activity. These fragments were separated by HPLC and used for binding studies with ATP and pyridoxal analogues.
J E, Churchich, Y T, Kim
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Chymotryptic digestion of sheep brain pyridoxal kinase, a dimer of identical subunits each of 40 kDa, yields two fragments of 24 and 16 kDa with concomitant loss of catalytic activity. These fragments were separated by HPLC and used for binding studies with ATP and pyridoxal analogues.
J E, Churchich, Y T, Kim
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The interactions between biogenic amines and pyridoxal, pyridoxal phosphate, and pyridoxal kinase
Archives of Biochemistry and Biophysics, 1972Abstract The effect of biogenic amines on pyridoxal kinase activity has been investigated in vitro . Experiments with a purified beef brain pyridoxal kinase indicate that 3,4-dihydroxyphenylalanine (dopa), dopamine, norepinephrine, and serotonin inhibit the reaction, while tyrosine, tryptophan, and 5-hydroxytryptophan (5-HTP) have no effect. However,
J T, Neary +3 more
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Crystal structure of human pyridoxal kinase
Journal of Structural Biology, 2006Pyridoxal kinase, a member of the ribokinase superfamily, catalyzes the ATP-dependent phosphorylation reaction of vitamin B6 and is an essential enzyme in the formation of pyridoxal-5'-phosphate, a key cofactor for over 100 enzymes. Pyridoxal kinase is thus regarded as a potential target for pharmacological agents.
Peng, Cao +4 more
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Interaction between Pyridoxal Kinase and Pyridoxal-5-phosphate-Dependent Enzymes
Journal of Biochemistry, 2003The interactions of two pyridoxal-5-phosphate (PLP)-dependent enzymes, alanine aminotransferase (ALT) and glutamate decarboxylase (GAD), with pyridoxal kinase (PK) were studied by fluorescence polarization as well as surface plasmon resonance techniques. The results demonstrated that PK can specifically bind to ALT and GAD.
Pik-Yuen, Cheung +7 more
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Pyridoxal kinase immunoreactivity in rabbit brain
Neurochemical Research, 1994Murine polyclonal antibody against purified bovine brain pyridoxal kinase (EC 2.7.1.35) was generated and showed cross-reactivity with rabbit brain pyridoxal kinase. This antibody was used to immunohistochemically examine the distribution of pyridoxal kinase in the rabbit brain.
K, Ohkawa +5 more
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