Results 131 to 140 of about 3,196 (237)

Vobramitamab duocarmazine, an anti–B7‐H3 antibody–drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion

open access: yesCancer, Volume 132, Issue 15, 1 August 2026.
Abstract Background Vobramitamab duocarmazine is an investigational antibody–drug conjugate (ADC) targeting B7 homolog 3 (B7‐H3) with a cytotoxic duocarmycin‐based DNA‐alkylating payload. This study evaluated its safety and antitumor activity in advanced solid tumors.
Eugene Shenderov   +20 more
wiley   +1 more source

Safety and Effectiveness of Denileukin Diftitox‐cxdl in Patients With Relapsed/Refractory Peripheral T‐Cell Lymphoma and Cutaneous T‐Cell Lymphoma: An All‐Case Post‐Marketing Study in Japan

open access: yesCancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Introduction Denileukin diftitox (DD)‐cxdl, a fusion protein comprising diphtheria toxin fragments and human interleukin‐2, is a treatment for peripheral T‐cell lymphoma (PTCL) and cutaneous T‐cell lymphoma (CTCL). Previous trials have enrolled a limited number of patients, and there is a need to evaluate DD‐cxdl in a more diverse population ...
Tatsuro Jo   +3 more
wiley   +1 more source

Molecular Genetics of Hepatozoon canis With a Note on Effect of Parasite on the Complete Blood Count Profile of Canine Hosts

open access: yesEcology and Evolution, Volume 16, Issue 8, August 2026.
A total of 654 blood samples were collected from healthy dogs in Punjab and Khyber Pakhtunkhwa provinces in Pakistan and screened for the presence of Hepatozoon canis. Genetic diversity of the detected H. canis DNA, infection‐associated risk factors, and changes in the complete blood count of the host due to parasitic activity were also evaluated.
Madiha Rasool   +14 more
wiley   +1 more source

Active Vaccination Strategies for Alzheimer's Disease: An Expanded Review

open access: yesEuropean Journal of Immunology, Volume 56, Issue 8, August 2026.
Overview of immunotherapeutic strategies targeting Alzheimer's disease (AD) pathology and their clinical implications. (Left) Key neuropathological hallmarks of AD, including extracellular amyloid‐beta (Aβ) aggregates and intraneuronal hyperphosphorylated Tau (phospho‐Tau), converge to produce synaptic failure, neuroinflammation and neuronal ...
Antonella Comitato   +2 more
wiley   +1 more source

Chaetocarpus castanocarpus Bark Extract Alleviates Pain, Pyrexia, Diarrhea, Hyperglycemia, and Oxidative Stress: Evidence From Integrated In Vitro and In Vivo Studies

open access: yesFood Science &Nutrition, Volume 14, Issue 8, August 2026.
Graphical abstract illustrating Chaetocarpus castanocarpus bark extract alleviates pain, pyrexia, diarrhea, hyperglycemia, and oxidative stress: Evidence from integrated in vitro and in vivo studies. ABSTRACT There is a history of using the medicinal plant Chaetocarpus genus, native to Southeast Asia, to treat a wide range of illnesses.
Rakibur Rahman   +10 more
wiley   +1 more source

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