Vagus nerve stimulation inhibits pyroptosis and improves outcome of cerebral ischemic stroke by upregulating osteopontin (SPP1) to disturb ASC oligomerization. [PDF]
Wen J+10 more
europepmc +1 more source
Burn the house, save the day: pyroptosis in pathogen restriction [PDF]
Boucher, Dave+2 more
core +1 more source
ABSTRACT Hepatocellular carcinoma (HCC) exhibits a high global morbidity rate and ranks as the fourth leading cause of cancer‐related mortality worldwide. In response to the urgent need for effective HCC treatments, naturally occurring, botanical‐driven compounds have gained increasing attention.
Bing Shi+3 more
wiley +1 more source
Transition of cellular senescence to pyroptosis mediates recurrence of small cell lung cancer after chemotherapy. [PDF]
Ma L+13 more
europepmc +1 more source
Recombinant CC16 inhibits NLRP3/caspase-1-induced pyroptosis through p38 MAPK and ERK signaling pathways in the brain of a neonatal rat model with sepsis [PDF]
Ruixi Zhou+6 more
openalex +1 more source
ABSTRACT Lung ischemia/reperfusion injury (LIRI) is a primary contributor to morbidity and mortality following lung transplantation. Dexmedetomidine (DEX) protects the lungs from I/R injury, but the underlying mechanisms remain uncertain. This paper examined the protective effect of DEX in LIRI and elucidated the potential regulation involved. LIRI was
Chun‐Huan Hu+4 more
wiley +1 more source
Inhibition of Caspase-3/GSDME Pathway-Mediated Pyroptosis of Renal Tubular Epithelial Cells by Dagliflozin in the Pathogenesis of Diabetic Kidney Disease and Study of Its Mechanism. [PDF]
Jiang H, Gao M, Liu J, Yang L, Liu L.
europepmc +1 more source
Caspase-11 Mediates Pyroptosis of Tubular Epithelial Cells and Septic Acute Kidney Injury [PDF]
Zhiming Ye+11 more
openalex +1 more source
ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) is associated with morbidity and mortality. Ferroptosis is associated with the pathophysiology of SA‐AKI. Here, we investigated the role of LIM and cysteine‐rich domain 1 (LMCD1) in the regulation of ferroptosis during SA‐AKI progression.
You‐Qi Zhang+5 more
wiley +1 more source
Neobractatin and Trametinib Synergistically Induce Apoptosis and Gasdermin E-Dependent Pyroptosis in Pancreatic Cancer Cells. [PDF]
Tan J+7 more
europepmc +1 more source