Results 321 to 330 of about 82,547 (381)

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

NPC1 as a novel therapeutic target for induction of pyroptosis in cancers. [PDF]

Biomark Res
Zhang C, Wang Q, Su P, Qian J, Guo Q, Wu W, Duan R, Zhang Y, Zu Y, Zhong L, Xiao L, Yi Q.   +11 more
europepmc   +1 more source

Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF‐κB Pathway Suppression

Oral Diseases, EarlyView.
ABSTRACT Objective Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.
Conglin Du, Zi Yang, Yang Yang, Chunmei Zhang, Hideaki Kagami, Xianqi Li, Liang Hu, Junji Xu, Jian Zhou   +8 more
wiley   +1 more source

USP7 overexpression prevents the progression of clear cell renal cell carcinoma by enhancing pyroptosis via TRIP12 deubiquitination. [PDF]

Cancer Biol Ther
Li H, Ning Y, Yu J, Chen Y, He Q, Jin J.
europepmc   +1 more source

Lesion Formation in Cardiac Pulsed‐Field Ablation: Acute to Chronic Cellular Level Changes

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT As pulsed‐field ablation (PFA) emerges as a promising therapy for atrial arrhythmias, an understanding of the cellular injury to cardiac tissue is critical to evaluating and interpreting results for each PFA system. This review aims to detail the mechanism of cell death for PFA, compare the cell death mechanism to thermal ablation modalities ...
Kara Garrott, Savannah Bifulco, David Ramirez, Brendan Koop   +3 more
wiley   +1 more source

miR-129-5p regulates HMGB1/RAGE axis to inhibit pyroptosis and ameliorate cervical epithelial cell deterioration. [PDF]

Eur J Histochem
Wang H, Sidike D, Liu P, Suo L, Niyazi H.   +4 more
europepmc   +1 more source

Photodynamic treatment in glioma: Metabolic and structural evaluation after therapy

Photochemistry and Photobiology, EarlyView.
PDT with chlorin e6 reduced mitochondrial membrane potential and induced gliosarcoma cell death, mainly via apoptosis and subsequently necrosis. Microscopy and flow cytometry confirmed cytoskeletal disorganization and morphological changes. These findings highlight PDT with Ce6 as a promising therapeutic alternative for gliosarcomas, showing strong ...
Marina Gabriela Teixeira, Luciana Maria Cortez Marcolino, Juliana Guerra Pinto, Rainara Moreno Sanches de Almeida, Isabelle Ferreira, Juliana Ferreira‐Strixino   +5 more
wiley   +1 more source

Calycosin attenuates mitochondrial damage and pyroptosis in heart failure via the Nrf2/ROS/TXNIP pathway. [PDF]

Int J Mol Med
Yuan HJ, Han QC, Yu YD, Yu H, Liu XJ, Xue YT, Li Y.   +6 more
europepmc   +1 more source

O-GlcNAcylation Mediated by OGA Activates NEK7/NLRP3 Pathway to Promote Pyroptosis in Parkinson's Disease. [PDF]

J Cell Mol Med
Wang Z, Liu Y, Ma L, Sun H, Tang Y.
europepmc   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

Periodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez, R. M. Arce, Camila Pinheiro Furquim, Cristiane Gonçalves, Alpdogan Kantarci, Magda Feres, Nidia C. Castro dos Santos   +6 more
wiley   +1 more source