Results 341 to 350 of about 82,547 (381)

Microglial pyroptosis as a therapeutic target after traumatic spinal cord injury: current progress and future directions. [PDF]

Front Immunol
Shi L, Qian Q, Xie J, Yang T, Zhao X, Meng X, Dai J, Jin Q.   +7 more
europepmc   +1 more source

Pyroptosis-Related Genes as Prognostic Biomarkers and Immune Infiltration Features in Sepsis-Induced ARDS: A Single-Cell and Bulk RNA-Sequencing Analysis. [PDF]

J Inflamm Res
Zhang P, Xu CL, Xu L, Wu JJ, Wang L.
europepmc   +1 more source

T3SS effector EseJ in Edwardsiella piscicida inhibits PANoptosis in macrophages. [PDF]

Commun Biol
He TT, Tang PY, Jiang XL, Sun SS, Nie P, Xie HX.   +5 more
europepmc   +1 more source

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Gasdermins and pyroptosis in the kidney

Nature Reviews Nephrology, 2023
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
Esteban E. Elias, Brayden Lyons, Daniel A. Muruve   +2 more
openaire   +3 more sources

Pyroptosis and pyroptosis-inducing cancer drugs

Acta Pharmacologica Sinica, 2022
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death.
Fan, Yang, Sahana N, Bettadapura, Mark S, Smeltzer, Hua, Zhu, Shanzhi, Wang   +4 more
openaire   +2 more sources

ZIF-8 Nanoparticles Evoke Pyroptosis for High-Efficiency Cancer Immunotherapy.

Angewandte Chemie, 2023
Although zeolitic imidazolate framework-8 (ZIF-8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF-8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase-1 ...
Binbin Ding, Hao Chen, Jia Tan, Qi Meng, Pan Zheng, Ping'an Ma, Jun Lin   +6 more
semanticscholar   +1 more source

Pyroptosis in diabetic nephropathy

Clinica Chimica Acta, 2021
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro ...
Md. Abdul Aziz, Fahad Munir, Abdullah Al Mamun, Yanqing Wu, Muhammad Zaeem, Suzia Aktar Suchi, Eman Alyafeai, Anjuman Ara Mimi, Jian Xiao   +8 more
openaire   +3 more sources

Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Advances in Materials, 2023
Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting the effect of cancer immunotherapy.
Yuqi Tang, H. Bisoyi, Xu‐Man Chen, Zhiyang Liu, Xiao Chen, Shu Zhang, Quan Li   +6 more
semanticscholar   +1 more source