Results 351 to 360 of about 77,046 (386)

Gasdermins and pyroptosis in the kidney

Nature Reviews Nephrology, 2023
Pyroptosis is a form of regulated cell death that is mediated by the membrane-targeting, pore-forming gasdermin family of proteins. Pyroptosis was initially described as a caspase 1- and inflammasome-dependent cell death pathway typified by the loss of membrane integrity and the secretion of cytokines such as IL-1β.
E. Elías, Brayden Lyons, D. Muruve
semanticscholar   +3 more sources

Pyroptosis and pyroptosis-inducing cancer drugs

Acta Pharmacologica Sinica, 2022
Pyroptosis, an inflammatory form of lytic cell death, is a type of cell death mediated by the gasdermin (GSDM) protein family. Upon recognizing exogenous or endogenous signals, cells undergo inflammasome assembly, GSDM cleavage, the release of proinflammatory cytokines and other cellular contents, eventually leading to inflammatory cell death.
Fan, Yang, Sahana N, Bettadapura, Mark S, Smeltzer, Hua, Zhu, Shanzhi, Wang   +4 more
openaire   +2 more sources

ZIF-8 Nanoparticles Evoke Pyroptosis for High-Efficiency Cancer Immunotherapy.

Angewandte Chemie, 2023
Although zeolitic imidazolate framework-8 (ZIF-8) has been applied in various tumor therapies, the intrinsic immunogenicity remains unclear. Here, we initiatively discover that ZIF-8 nanoparticles (NPs) can intrinsically induce pyroptosis by a caspase-1 ...
Binbin Ding, Hao Chen, Jia Tan, Qi Meng, Pan Zheng, Ping'an Ma, Jun Lin   +6 more
semanticscholar   +1 more source

Pyroptosis in diabetic nephropathy

Clinica Chimica Acta, 2021
Diabetic nephropathy (DN), a sterile inflammatory disease, is a serious complication of diabetes mellitus. However, recent evidence indicates that pyroptosis, a new term for pro-inflammatory cell death featured by gasdermin D (GSDMD)-stimulated plasma membrane pore generation, cell expansion and rapid lysis with the extensive secretion of pro ...
Md. Abdul Aziz, Fahad Munir, Abdullah Al Mamun, Yanqing Wu, Muhammad Zaeem, Suzia Aktar Suchi, Eman Alyafeai, Anjuman Ara Mimi, Jian Xiao   +8 more
openaire   +3 more sources

Pyroptosis‐Mediated Synergistic Photodynamic and Photothermal Immunotherapy Enabled by a Tumor‐Membrane‐Targeted Photosensitive Dimer

Advances in Materials, 2023
Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting the effect of cancer immunotherapy.
Yuqi Tang, H. Bisoyi, Xu‐Man Chen, Zhiyang Liu, Xiao Chen, Shu Zhang, Quan Li   +6 more
semanticscholar   +1 more source

Mitochondrial‐Targeted Delivery of Polyphenol‐Mediated Antioxidases Complexes against Pyroptosis and Inflammatory Diseases

Advances in Materials, 2023
Excess accumulation of mitochondrial reactive oxygen species (mtROS) is a key target for inhibiting pyroptosis‐induced inflammation and tissue damage. However, targeted delivery of drugs to mitochondria and efficient clearance of mtROS remain challenging.
Jiaojiao Zhang, Bingqiang Gao, Binglin Ye, Zhongquan Sun, Zhefeng Qian, Lisha Yu, Yanli Bi, Lie Ma, Yuan Ding, Yang Du, Weilin Wang, Zhengwei Mao   +11 more
semanticscholar   +1 more source

Self‐Destructive Copper Carriers Induce Pyroptosis and Cuproptosis for Efficient Tumor Immunotherapy Against Dormant and Recurrent Tumors

Advances in Materials, 2023
Activating the strong immune system is a key initiative to counteract dormant tumors and prevent recurrence. Herein, self‐destructive and multienzymatically active copper‐quinone‐GOx nanoparticles (abbreviated as CQG NPs) have been designed to induce ...
Luying Qiao, G. Zhu, Tengfei Jiang, Yanrong Qian, Qianqian Sun, Guanghui Zhao, Haidong Gao, Chunxia Li   +7 more
semanticscholar   +1 more source

New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Apoptosis, 2023
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen, Yuxiang, Sun, Siliang, Wang, Jingyan, Xu   +3 more
openaire   +2 more sources

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Science, 2020
Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes to target cells through perforin ...
Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang, Lianjun Shen, W. Han, L. Shen, Jingjin Ding, F. Shao   +14 more
semanticscholar   +1 more source