Results 351 to 360 of about 82,547 (381)

Mitochondrial‐Targeted Delivery of Polyphenol‐Mediated Antioxidases Complexes against Pyroptosis and Inflammatory Diseases

Advances in Materials, 2023
Excess accumulation of mitochondrial reactive oxygen species (mtROS) is a key target for inhibiting pyroptosis‐induced inflammation and tissue damage. However, targeted delivery of drugs to mitochondria and efficient clearance of mtROS remain challenging.
Jiaojiao Zhang, Bingqiang Gao, Binglin Ye, Zhongquan Sun, Zhefeng Qian, Lisha Yu, Yanli Bi, Lie Ma, Yuan Ding, Yang Du, Weilin Wang, Zhengwei Mao   +11 more
semanticscholar   +1 more source

New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

Apoptosis, 2023
Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell ...
Qiaoyun, Chen, Yuxiang, Sun, Siliang, Wang, Jingyan, Xu   +3 more
openaire   +2 more sources

Self‐Destructive Copper Carriers Induce Pyroptosis and Cuproptosis for Efficient Tumor Immunotherapy Against Dormant and Recurrent Tumors

Advances in Materials, 2023
Activating the strong immune system is a key initiative to counteract dormant tumors and prevent recurrence. Herein, self‐destructive and multienzymatically active copper‐quinone‐GOx nanoparticles (abbreviated as CQG NPs) have been designed to induce ...
Luying Qiao, G. Zhu, Tengfei Jiang, Yanrong Qian, Qianqian Sun, Guanghui Zhao, Haidong Gao, Chunxia Li   +7 more
semanticscholar   +1 more source

Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response.

Journal of the American Chemical Society, 2023
Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by the release of pro-inflammatory cytokines.
Mingle Li, Jungryun Kim, H. Rha, Subin Son, Matthew S Levine, Yunjie Xu, J. Sessler, Jong Seung Kim   +7 more
semanticscholar   +1 more source

Molecular Mechanisms of Pyroptosis

2023
Pyroptosis is a regulated form of cell death that leads to inflammation and plays a role in many different diseases. Pyroptosis was initially defined by the dependence on caspase-1, a protease which is activated by innate immune signaling complexes called inflammasomes.
Marisa J, Anderson, Andreas B, den Hartigh, Susan L, Fink   +2 more
openaire   +2 more sources

A checkpoint for pyroptosis

Science Signaling, 2020
The nuclear pool of an immune checkpoint protein promotes pyroptosis and tumor necrosis downstream of TNFα.
openaire   +2 more sources

The palmitoylation of gasdermin D directs its membrane translocation and pore formation during pyroptosis

Science immunology
Plasma membrane perforation elicited by caspase cleavage of the gasdermin D (GSDMD) N-terminal domain (GSDMD-NT) triggers pyroptosis. The mechanisms underlying GSDMD membrane translocation and pore formation are not fully understood.
A. Balasubramanian, A. Hsu, Laxman Ghimire, Muhammad Tahir, Pascal Devant, Pietro Fontana, Gang Du, Xing Liu, Dang Fabin, Hiroto Kambara, Xuemei Xie, Fei Liu, Tomoya Hasegawa, Rong Xu, H. Yu, Mei Chen, Steven Kolakowski, S. Trauger, M. R. Larsen, Wenyi Wei, Haoying Wu, Jonathan C. Kagan, Judy Lieberman, Hongbo R. Luo   +23 more
semanticscholar   +1 more source

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

Science, 2020
Granzyme A lights a fire Cytotoxic T cells and natural killer cells use several strategies to kill infected or transformed cells. One such pathway entails the delivery of a family of serine proteases called granzymes to target cells through perforin ...
Zhiwei Zhou, Huabin He, Kun Wang, Xuyan Shi, Yupeng Wang, Ya Su, Yao Wang, Da Li, Wang Liu, Yongliang Zhang, Lianjun Shen, W. Han, L. Shen, Jingjin Ding, F. Shao   +14 more
semanticscholar   +1 more source

Targeting Src reactivates pyroptosis to reverse chemoresistance in lung and pancreatic cancer models

Science Translational Medicine, 2023
Pancreatic and lung cancers frequently develop resistance to chemotherapy-induced cell apoptosis during the treatment, indicating that targeting nonapoptotic-related pathways, such as pyroptosis, can be an alternative cancer treatment strategy ...
Liangping Su, Yitian Chen, Cheng Huang, Sangqing Wu, Xiaojuan Wang, Xinbao Zhao, Qiuping Xu, Ruipu Sun, Xiangzhan Kong, Xue Jiang, Xiaoyi Qiu, Xiaoming Huang, Minghui Wang, Ping-Pui Wong   +13 more
semanticscholar   +1 more source

Programmed Targeting Pyruvate Metabolism Therapy Amplified Single‐Atom Nanozyme‐Activated Pyroptosis for Immunotherapy

Advances in Materials
Increasing cellular immunogenicity and reshaping the immune tumor microenvironment (TME) are crucial for antitumor immunotherapy. Herein, this work develops a novel single‐atom nanozyme pyroptosis initiator: UK5099 and pyruvate oxidase (POx)‐co‐loaded Cu‐
R. Niu, Yang Liu, Bo Xu, Ruiping Deng, Shijie Zhou, Yue Cao, Wanying Li, Hao Zhang, Haiyang Zheng, Shuyan Song, Yinghui Wang, Hongjie Zhang   +11 more
semanticscholar   +1 more source